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<p>The weak interfacial binding of polylactic acid (PLA) to the nanoscale reinforcement phase limits its wide application in bone tissue engineering scaffolds. Herein, halloysite nanotubes were surface functionalized by dopamine (DA) modification and then Polylactic acid/halloysite nanotubes composite scaffold (PLA/HNTs) with improved interfacial properties was prepared through selective laser sintering. Compared with PLA scaffolds, Polylactic acid/2% Dopamine-modified halloysite nanotubes composite scaffold (PLA/2% D-HNTs) achieved the best mechanical reinforcement effect, with compressive strength and modulus increased by 99.6% and 77.7%, respectively. The mechanical enhancement mainly results from the construction of interfacial molecular bridges and the synergistic effect of fracture toughening: (i) the amino groups of Polydopamine (PDA) formed hydrogen bonds with the hydroxyl groups of HNTs, while the catechol groups of PDA interacted with the ester groups of PLA through hydrogen bonding; (ii) the bridging, deflection and branching effects generated during crack propagation significantly increased the energy dissipation, and further enhancing the mechanical strength of the composite scaffold. Moreover, Biomineralization evaluation demonstrated that the scaffold had excellent bioactivity potential, which was able to induce the formation of apatite under simulated physiological conditions. Live/dead cell staining confirmed that the composite scaffold has good cell compatibility and provides a favorable microenvironment for the survival of MC3T3-E1 cells. These characteristics provide valuable references for the application of PLA/HNTs composite scaffold in bone tissue engineering.</p>

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Dopamine-modified halloysite nanotubes reinforced polylactic acid composite scaffolds: interface bonding and bioactivity

  • 期刊论文

  • 发表日期：

    2025年12月5日

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  • Bo Xu,
  • Dongying Li,
  • Meigui Chen,
  • Bin Wang,
  • Zixiong Zhou,
  • Jianfei Zhang,
  • Zonghan Li,
  • Changfeng Li,
  • Yong Xu,
  • Mengqi Li

摘要

The weak interfacial binding of polylactic acid (PLA) to the nanoscale reinforcement phase limits its wide application in bone tissue engineering scaffolds. Herein, halloysite nanotubes were surface functionalized by dopamine (DA) modification and then Polylactic acid/halloysite nanotubes composite scaffold (PLA/HNTs) with improved interfacial properties was prepared through selective laser sintering. Compared with PLA scaffolds, Polylactic acid/2% Dopamine-modified halloysite nanotubes composite scaffold (PLA/2% D-HNTs) achieved the best mechanical reinforcement effect, with compressive strength and modulus increased by 99.6% and 77.7%, respectively. The mechanical enhancement mainly results from the construction of interfacial molecular bridges and the synergistic effect of fracture toughening: (i) the amino groups of Polydopamine (PDA) formed hydrogen bonds with the hydroxyl groups of HNTs, while the catechol groups of PDA interacted with the ester groups of PLA through hydrogen bonding; (ii) the bridging, deflection and branching effects generated during crack propagation significantly increased the energy dissipation, and further enhancing the mechanical strength of the composite scaffold. Moreover, Biomineralization evaluation demonstrated that the scaffold had excellent bioactivity potential, which was able to induce the formation of apatite under simulated physiological conditions. Live/dead cell staining confirmed that the composite scaffold has good cell compatibility and provides a favorable microenvironment for the survival of MC3T3-E1 cells. These characteristics provide valuable references for the application of PLA/HNTs composite scaffold in bone tissue engineering.