<p>Burn injuries pose a major global health burden, often leading to extensive tissue destruction, disfigurement, functional loss, and prolonged morbidity. According to the World Health Organization, over 11&#xa0;million individuals annually require medical care for burn wounds, with a disproportionate burden in low- and middle-income nations. Conventional wound management strategies including cellulose-based dressings remain limited in their capacity to support regenerative healing, prevent infection, or resolve inflammation in deep or chronic burns. In recent years, bioinspired polymeric constructs have emerged as transformative platforms in advanced burn care. Designed to emulate the structural and biochemical features of the extracellular matrix, these materials exhibit tailored biocompatibility, controlled degradability, and mechanical robustness. Their modular architecture allows for the incorporation of antimicrobial, anti-inflammatory, and antioxidative agents, as well as the release of growth factors. Notably, hydrogel matrices, electrospun nanofibrous systems, and hybrid natural-synthetic composites have demonstrated superior outcomes in terms of cellular infiltration, angiogenesis, re-epithelialization, and matrix remodelling. This review explores the evolution and current landscape of bioinspired scaffold technologies in the context of burn wound healing. By converging advances in polymer chemistry, nanotechnology, and regenerative biology, bioinspired polymeric scaffolds represent a paradigm shift in burn wound therapeutics and, thereby redefining the future of regenerative burn care.</p> Graphical abstract <p></p>