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<p>Black seed (Nigella sativa) contains diverse active compounds that offer remarkable therapeutic benefits. Electrospinning is a technique that employs a high-voltage electrical source to manipulate polymer solutions, resulting in the production of nanofibers. microporous materials were used to electrospin nanofibers of polyvinyl alcohol (PVA) and chitosan (CS) infused with NS(mension full name first) extract. The characterisation of the nanofibers included an examination of their structure, porosity, and physical properties using gas chromatography-mass spectrometry (GC-MS), water contact angle assessments, scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy (FT-IR). SEM demonstrated consistent and defect-free morphologies of the synthesized nanofibers, with an average diameter of 463.8 ± 5.85&#xa0;nm. Measurements of fiber wettability and water contact angle were conducted. The findings showed that the electrospun PVA/CS/NS nanofiber mats exhibited enhanced wettability and a higher contact angle in comparison to PVA/CS and PVA nanofibers, corroborated by DPPH antioxidant activity and antibacterial efficacy against Escherichia coli and Staphylococcus aureus, in addition to their application in wound dressing. The study concluded that the PVA/CS nanofiber mats infused with Nigella sativa extract (NS) exhibit favorable biological applications and biocompatibility. Further research is recommended to examine the effects of this compound in medical applications.</p>

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Electrospun Nigella sativa-loaded polyvinyl alcohol/chitosan hybrid bio-nanocomposites have antioxidant, antibacterial, and possible wound-dressing qualities

  • 期刊论文

  • 发表日期：

    2025年12月23日

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  • Qasim Shakir Kadhim,
  • Maher Hassan Rasheed,
  • Raya Ali Abed

摘要

Black seed (Nigella sativa) contains diverse active compounds that offer remarkable therapeutic benefits. Electrospinning is a technique that employs a high-voltage electrical source to manipulate polymer solutions, resulting in the production of nanofibers. microporous materials were used to electrospin nanofibers of polyvinyl alcohol (PVA) and chitosan (CS) infused with NS(mension full name first) extract. The characterisation of the nanofibers included an examination of their structure, porosity, and physical properties using gas chromatography-mass spectrometry (GC-MS), water contact angle assessments, scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy (FT-IR). SEM demonstrated consistent and defect-free morphologies of the synthesized nanofibers, with an average diameter of 463.8 ± 5.85 nm. Measurements of fiber wettability and water contact angle were conducted. The findings showed that the electrospun PVA/CS/NS nanofiber mats exhibited enhanced wettability and a higher contact angle in comparison to PVA/CS and PVA nanofibers, corroborated by DPPH antioxidant activity and antibacterial efficacy against Escherichia coli and Staphylococcus aureus, in addition to their application in wound dressing. The study concluded that the PVA/CS nanofiber mats infused with Nigella sativa extract (NS) exhibit favorable biological applications and biocompatibility. Further research is recommended to examine the effects of this compound in medical applications.