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<p>The primary objective of the current investigation was to develop innovative hydrogels composed of oxidized sterculia gum (OSG) and coumaric acid-grafted gelatin (CA-<i>g</i>-gelatin) and characterize for their wound healing capacities. In this context, CA was conjugated to gelatin template through amide coupling reaction, yielding CA-<i>g</i>-gelatin. The OSG was subsequently synthesized <i>via</i> periodate oxidation of native sterculia gum. The OSG could further crosslinked with amino moieties of pristine gelatin or CA-<i>g</i>-gelatin through Schiff’s base reactions. The obtained OSG, OSG/gelatin and OSG/CA-<i>g</i>-gelatin were lyophilized to afford various hydrogels (F-1–F-3). The structural properties, thermal characteristics and crystallinity behaviour of the hydrogels were tested employing various analytical techniques. The SEM images of hydrogels revealed the interconnected porous architectures. Several hydrogels demonstrated a prompt wetting time (15–75&#xa0;s), acceptable porosity (65–92%), water vapor transmission rates (WVTR, 2258–2592&#xa0;g/m<sup>2</sup>/day), water retention capacity and pH-responsive swelling behaviour. Among different hydrogels, the CA grafted hydrogels (F-3) bestowed superior hemocompatibility and DPPH-free radical scavenging activity. These were also most effective in promoting the adhesion, proliferation and migration of fibroblast cells. The outcomes of the research endeavours suggested that the newly synthesized hydrogels had remarkable potentials as effective wound dressings for enhanced wound management.</p>

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Fabrication and characterization of oxidized sterculia gum/coumaric acid-g-gelatin based hydrogels as potential wound dressings

  • 期刊论文

  • 发表日期：

    2025年12月10日

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  • Prithweesom Das,
  • Manonayan Singha,
  • Soumadwip Das,
  • Dipanwita Ghosh,
  • Niladri Mandal,
  • Hriday Bera,
  • Tarun Patel,
  • Darakhshan Begum,
  • Paramita Paul,
  • Yasir Faraz Abbasi,
  • Nanda Gopal Sahoo,
  • Subhabrata Ray,
  • Balaram Ghosh

摘要

The primary objective of the current investigation was to develop innovative hydrogels composed of oxidized sterculia gum (OSG) and coumaric acid-grafted gelatin (CA-g-gelatin) and characterize for their wound healing capacities. In this context, CA was conjugated to gelatin template through amide coupling reaction, yielding CA-g-gelatin. The OSG was subsequently synthesized via periodate oxidation of native sterculia gum. The OSG could further crosslinked with amino moieties of pristine gelatin or CA-g-gelatin through Schiff’s base reactions. The obtained OSG, OSG/gelatin and OSG/CA-g-gelatin were lyophilized to afford various hydrogels (F-1–F-3). The structural properties, thermal characteristics and crystallinity behaviour of the hydrogels were tested employing various analytical techniques. The SEM images of hydrogels revealed the interconnected porous architectures. Several hydrogels demonstrated a prompt wetting time (15–75 s), acceptable porosity (65–92%), water vapor transmission rates (WVTR, 2258–2592 g/m2/day), water retention capacity and pH-responsive swelling behaviour. Among different hydrogels, the CA grafted hydrogels (F-3) bestowed superior hemocompatibility and DPPH-free radical scavenging activity. These were also most effective in promoting the adhesion, proliferation and migration of fibroblast cells. The outcomes of the research endeavours suggested that the newly synthesized hydrogels had remarkable potentials as effective wound dressings for enhanced wound management.