Scholarlink

<p>Sodium alginate has garnered significant attention in the biomedical field due to its unique gelation properties through ionic crosslinking, biocompatibility, biodegradability, and non-immunogenic nature. This review critically examines current developments in the creation and implementation of smart composite materials based on sodium alginate, which are produced using various three-dimensional (3D) printing processes for biomedical applications. The structural features and sources of SA that make it a prime option for biofabrication are well covered in the manuscript. Various 3D printing modalities, such as extrusion-based printing, inkjet printing, stereolithography, and laser-assisted printing, are given special attention. An emphasis on the benefits, drawbacks, and working principles of alginate-based systems to their applications. Important printing parameters, such as surface tension, viscosity, and shear-thinning behavior, are methodically covered, as are other significant elements, including printing speed, nozzle diameter, and crosslinking kinetics. Additionally, to improve the mechanical, rheological, and biological performance of SA-based inks, the review investigates the addition of several functional additives (such as nanomaterials, bioactive compounds, and stimuli-responsive polymers). Ionic crosslinking, freeze-drying, UV curing, and thermal dehydration are examples of post-processing techniques that are examined for their effects on the stability, microstructure, porosity, and biofunctionality of printed structures. A thorough discussion is provided of the biomedical applications of 3D-printed SA-based materials, with an emphasis on wound healing treatments, controlled drug delivery systems, and tissue engineering (including cartilage, bone, skin, and vascular structures). Limited mechanical strength, poor cell adhesion, and inadequate vascularization are some of the issues that still exist despite significant advancements. The review’s conclusion identifies future research approaches that are crucial to transforming alginate-based biomaterials into clinically viable therapeutic platforms, including the creation of hybrid bioinks and scalable manufacturing.</p> Graphical abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

A critical review of 3D-printed alginate-based materials for biomedical applications

  • 期刊论文

  • 发表日期：

    2025年11月11日

查看全文
  • Kajal Yadav,
  • Anju Singhwane,
  • Kamna Chaturvedi,
  • Ranjan K. Mohapatra,
  • Sarika Verma

摘要

Sodium alginate has garnered significant attention in the biomedical field due to its unique gelation properties through ionic crosslinking, biocompatibility, biodegradability, and non-immunogenic nature. This review critically examines current developments in the creation and implementation of smart composite materials based on sodium alginate, which are produced using various three-dimensional (3D) printing processes for biomedical applications. The structural features and sources of SA that make it a prime option for biofabrication are well covered in the manuscript. Various 3D printing modalities, such as extrusion-based printing, inkjet printing, stereolithography, and laser-assisted printing, are given special attention. An emphasis on the benefits, drawbacks, and working principles of alginate-based systems to their applications. Important printing parameters, such as surface tension, viscosity, and shear-thinning behavior, are methodically covered, as are other significant elements, including printing speed, nozzle diameter, and crosslinking kinetics. Additionally, to improve the mechanical, rheological, and biological performance of SA-based inks, the review investigates the addition of several functional additives (such as nanomaterials, bioactive compounds, and stimuli-responsive polymers). Ionic crosslinking, freeze-drying, UV curing, and thermal dehydration are examples of post-processing techniques that are examined for their effects on the stability, microstructure, porosity, and biofunctionality of printed structures. A thorough discussion is provided of the biomedical applications of 3D-printed SA-based materials, with an emphasis on wound healing treatments, controlled drug delivery systems, and tissue engineering (including cartilage, bone, skin, and vascular structures). Limited mechanical strength, poor cell adhesion, and inadequate vascularization are some of the issues that still exist despite significant advancements. The review’s conclusion identifies future research approaches that are crucial to transforming alginate-based biomaterials into clinically viable therapeutic platforms, including the creation of hybrid bioinks and scalable manufacturing.

Graphical abstract