Simultaneous investigation of polyurethane nanocomposite foam drug release and its antibacterial properties and simulation of drug release rate
摘要
In this study, a soybean oil-based polyurethane foam (FNP) was successfully synthesized and utilized as a wound dressing incorporating a Zn–Ag LDH-loaded celecoxib formulation to modulate drug release for bone treatment. The research explored the drug release dynamics and the adsorption–desorption processes, along with evaluating the physical and chemical properties of the final nanocomposite foam product. Techniques such as Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) were employed. To assess the aging behavior of the polyurethane, the nanocomposite foam’s microstructure and pore size were analyzed. Release data indicated that FNP6Z5 demonstrated a maximum celecoxib release efficiency of approximately 73% over 150 h at pH 7.4. Furthermore, the drug-loading capacity for this sample was 22.2 μg/mL at the same pH. Cytotoxicity tests revealed that higher concentrations of Zn–Ag LDH enhanced the physical and chemical properties of the nanocomposite foams, subsequently increasing cell viability. The adsorption capacity of FNP6Z5 for celecoxib was calculated to be 240 mg.g − 1, based on Langmuir, Freundlich and Temkin adsorption isotherms. The activation energies for celecoxib adsorption onto the FNP6Z5 adsorbent were determined to be 90.7 kJ.mol−1 and 80.9 kJ.mol−1, respectively. These values suggest that the celecoxib adsorption onto FNP6Z5 occurs at a moderate rate, with activation energies ranging between 40 and 120 kJ.mol−1. The drug release model showed that this drug easily diffuses nanocomposite from the film and into the skin. The skin offers no resistance to drug release and acts as a sink, immediately removing the drug as soon as it enters the FNP6Z5 foam. Also, the layer thickness model showed that in long times, from a thin layer of FNP6Z5 foam at lower ratios of Dt/L, the higher drug release occurred.