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<p><i>Gracilaria salicornia</i> was used to synthesize nanoparticles from its aqueous extract, and <i>Padina gymnospora</i> was a source of sodium alginate (SA)-based hydrogel. The synthesized nanoparticles with sodium alginate, a nanocomposite (NC) thin film, termed GsAu/CeO₂/TiO₂NC, was successfully fabricated. The integration of SA with NC was investigated and confirmed using SEM, EDX, FT-IR, XRD, and TGA analyses. Thermostability of GsAu/CeO₂/TiO₂NC thin film was validated through thermogravimetric analysis (TGA) and viscosity of the fabricated NC was systematically assessed. The NC exhibited MICs of 6.25, 12.5 and 25&#xa0;μg/mL against <i>E. coli</i>, <i>Staphylococcus aureus</i> and <i>Candida albicans</i>. The NC thin film exhibited potent anti-infective properties, achieving biofilm inhibition efficiencies of 76.47 ± 0.98% for <i>E. coli</i>, 71.25 ± 0.40% for <i>S. aureus</i>, and 66.17 ± 0.53% for <i>C. albicans</i>. Also, it demonstrated mature biofilm eradication rates of 68.79 ± 0.52%, 60.64 ± 0.14%, and 57.62 ± 0.84%, respectively. The polydisperse produced GsAu/CeO<sub>2</sub>/TiO<sub>2</sub>NC thin film formed with different metallic NP concentrations, resulting in a fluctuating structure. The incorporation of metallic nanoparticles enhanced the pore size of SA polysaccharides in the nanocomposite, facilitating the successful structural formation. The NC demonstrated antioxidant activity at 0.8&#xa0;mg/mL, free&#xa0;radical scavenging at 70.64 ± 0.92%, and non-hemolytic potential at 0.5&#xa0;mg/mL. These results imply that the produced NC is suitable for elevated antimicrobial applications in anti-infective wound dressing.</p> Graphical abstract <p> Schematic representation of GsAu/CeO<sub>2</sub>/TiO<sub>2</sub> sodium alginate Nanocomposite thin film fabrication from <i>G. salicornia</i> and <i>P. gymnospora</i></p>

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Development of a seaweed-derived polymeric nanocomposite with anti-infective properties against wound pathogens

  • 期刊论文

  • 发表日期：

    2025年5月26日

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  • Vengateshwaran Thasu Dinakaran,
  • Henciya Santhaseelan,
  • Velmurugan Devendiran,
  • Muthukumar Krishnan,
  • Duan Jizhou,
  • Armstrong-Altrin John Selvamony,
  • Arthur James Rathinam

摘要

Gracilaria salicornia was used to synthesize nanoparticles from its aqueous extract, and Padina gymnospora was a source of sodium alginate (SA)-based hydrogel. The synthesized nanoparticles with sodium alginate, a nanocomposite (NC) thin film, termed GsAu/CeO₂/TiO₂NC, was successfully fabricated. The integration of SA with NC was investigated and confirmed using SEM, EDX, FT-IR, XRD, and TGA analyses. Thermostability of GsAu/CeO₂/TiO₂NC thin film was validated through thermogravimetric analysis (TGA) and viscosity of the fabricated NC was systematically assessed. The NC exhibited MICs of 6.25, 12.5 and 25 μg/mL against E. coli, Staphylococcus aureus and Candida albicans. The NC thin film exhibited potent anti-infective properties, achieving biofilm inhibition efficiencies of 76.47 ± 0.98% for E. coli, 71.25 ± 0.40% for S. aureus, and 66.17 ± 0.53% for C. albicans. Also, it demonstrated mature biofilm eradication rates of 68.79 ± 0.52%, 60.64 ± 0.14%, and 57.62 ± 0.84%, respectively. The polydisperse produced GsAu/CeO2/TiO2NC thin film formed with different metallic NP concentrations, resulting in a fluctuating structure. The incorporation of metallic nanoparticles enhanced the pore size of SA polysaccharides in the nanocomposite, facilitating the successful structural formation. The NC demonstrated antioxidant activity at 0.8 mg/mL, free radical scavenging at 70.64 ± 0.92%, and non-hemolytic potential at 0.5 mg/mL. These results imply that the produced NC is suitable for elevated antimicrobial applications in anti-infective wound dressing.

Graphical abstract

Schematic representation of GsAu/CeO2/TiO2 sodium alginate Nanocomposite thin film fabrication from G. salicornia and P. gymnospora