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<p>A xanthone glycoside mangiferin (MGF) was isolated from fern <i>Davallia solida</i> (Davalliaceae). MGF-entrapped gelatin (GT) hydrogels containing different concentrations of MGF were fabricated by solvent-casting methods. Functional group interactions of the hydrogels were analyzed by attenuated total reflectance–Fourier transform infrared spectroscopy. The morphology of the hydrogels with varied amounts of MGF exhibited a homogeneous smooth surface. The MGF release from the hydrogels increased in a dose-dependent manner, whereas the swelling ratio of the hydrogels decreased. The effect of MGF concentrations on antioxidant properties and cell behavior was further investigated. Compared with GT hydrogel, the loading of MGF led to a strong antioxidant activity based on DPPH and ABTS radical-scavenging activities, FRAP reducing power assay, and total antioxidant capacity. The MGF-loaded GT hydrogels were non-toxic to human dermal fibroblasts and keratinocyte cells. Therefore, MGF-loaded GT hydrogels with appropriate antioxidant activity, anti-inflammatory and biocompatibility could be a promising oxidation-resistant material for wound dressing and tissue engineering.</p>

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Mangiferin-loaded gelatin hydrogels with antioxidant and anti-inflammatory activities for wound dressing

  • 期刊论文

  • 发表日期：

    2025年5月13日

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  • Piyachat Chuysinuan,
  • Thanyaluck Thanyacharoen,
  • Wachirasak Thaisaeng,
  • Kriengsak Lirdprapamongkol,
  • Jisnuson Svasti,
  • Supanna Techasakul,
  • Somsak Ruchirawat,
  • Nopporn Thasana

摘要

A xanthone glycoside mangiferin (MGF) was isolated from fern Davallia solida (Davalliaceae). MGF-entrapped gelatin (GT) hydrogels containing different concentrations of MGF were fabricated by solvent-casting methods. Functional group interactions of the hydrogels were analyzed by attenuated total reflectance–Fourier transform infrared spectroscopy. The morphology of the hydrogels with varied amounts of MGF exhibited a homogeneous smooth surface. The MGF release from the hydrogels increased in a dose-dependent manner, whereas the swelling ratio of the hydrogels decreased. The effect of MGF concentrations on antioxidant properties and cell behavior was further investigated. Compared with GT hydrogel, the loading of MGF led to a strong antioxidant activity based on DPPH and ABTS radical-scavenging activities, FRAP reducing power assay, and total antioxidant capacity. The MGF-loaded GT hydrogels were non-toxic to human dermal fibroblasts and keratinocyte cells. Therefore, MGF-loaded GT hydrogels with appropriate antioxidant activity, anti-inflammatory and biocompatibility could be a promising oxidation-resistant material for wound dressing and tissue engineering.