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<p>Efficient synthesis of biodegradable and biocompatible polyester composite scaffold for tissue engineering application is still a major challenge. In this study, a three-dimensional porous structure of newly unsaturated polyester poly (glycerol sebacic itaconic acid) (PGSIt) scaffold was fabricated using solvent-free polycondensation and salt leaching technique. Furthermore, clay-incorporated PGSIt-based scaffolds were fabricated and their thermal stability, hydrophilicity, and cell viability were investigated. Fourier transform infrared spectroscopy confirmed the successful synthesis of PGSIt with proper interaction with clay mineral. Scanning electron microscopy revealed the porous structure of the PGSIt-based scaffolds with interconnected pores and proper dispersion of nano-clay in the polymeric matrix. The hydrophilic feature and thermal stability of the PGSIt-based scaffolds was enhanced by incorporation of clay mineral. The cultivation of mouse embryo fibroblast cells (L929) on PGSIt scaffolds showed proper cytocompatibility and cell attachment of this new bio-nanocomposite. Accordingly, PGSIt-based scaffolds can be a satisfactory candidate in soft tissue engineering as an unsaturated polyester which sheds light on the future development in regenerative medicine.</p> Graphical abstract <p></p>

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Tissue-engineered scaffold based on poly (glycerol sebacic itaconic acid)/clay nanocomposite using salt leaching process

  • 期刊论文

  • 发表日期：

    2025年3月28日

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  • Shaghayegh Hashempoor,
  • Najmeh Najmoddin,
  • Mohsen Mohammadi,
  • Saba Seyfikar,
  • Masoomeh Asgharnejad-laskoukalayeh,
  • Vahabodin Goodarzi

摘要

Efficient synthesis of biodegradable and biocompatible polyester composite scaffold for tissue engineering application is still a major challenge. In this study, a three-dimensional porous structure of newly unsaturated polyester poly (glycerol sebacic itaconic acid) (PGSIt) scaffold was fabricated using solvent-free polycondensation and salt leaching technique. Furthermore, clay-incorporated PGSIt-based scaffolds were fabricated and their thermal stability, hydrophilicity, and cell viability were investigated. Fourier transform infrared spectroscopy confirmed the successful synthesis of PGSIt with proper interaction with clay mineral. Scanning electron microscopy revealed the porous structure of the PGSIt-based scaffolds with interconnected pores and proper dispersion of nano-clay in the polymeric matrix. The hydrophilic feature and thermal stability of the PGSIt-based scaffolds was enhanced by incorporation of clay mineral. The cultivation of mouse embryo fibroblast cells (L929) on PGSIt scaffolds showed proper cytocompatibility and cell attachment of this new bio-nanocomposite. Accordingly, PGSIt-based scaffolds can be a satisfactory candidate in soft tissue engineering as an unsaturated polyester which sheds light on the future development in regenerative medicine.

Graphical abstract