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<p>Developing a multifunctional wound dressing that serves to protect, facilitate healing, and indicate the progress of wound recovery represents a novel investigative approach. In this study, a ternary blended hydrocolloid consisting of agar (AG), sodium alginate (SA), and gelatin (GN) was employed as a polymer matrix, serving as an encapsulation medium for purple allamanda extract (PAE), a natural pH indicator. The composite material was fabricated using a solvent casting technique. The hydrocolloids were characterized using FT-IR, SEM, UTM, XRD and water contact angle measurements. The hydrocolloids showed a good tensile strength value of about 33.9&#xa0;MPa and possess antibacterial, antioxidant, and hemocompatibility properties. The hydrocolloid degraded about 79% over 7&#xa0;days. The AG/SA/GN-PA showed 85% of cell viability against the L929 mouse cell line. Thus, this methodology presents cost-effectiveness, safety and a streamlined manufacturing process. Further studies were conducted to evaluate hydrocolloids as a feasible platform for practical applications in wound monitoring and healing.</p> Graphical abstract <p></p>

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Designing a pH-sensitive wound dressing: Harnessing purple allamanda extract for real-time healing monitoring and multifunctional therapeutic benefits

  • 期刊论文

  • 发表日期：

    2025年2月8日

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  • S. Gopika Devi,
  • S. Subasini,
  • M. Karthickraja,
  • Anitha Pius

摘要

Developing a multifunctional wound dressing that serves to protect, facilitate healing, and indicate the progress of wound recovery represents a novel investigative approach. In this study, a ternary blended hydrocolloid consisting of agar (AG), sodium alginate (SA), and gelatin (GN) was employed as a polymer matrix, serving as an encapsulation medium for purple allamanda extract (PAE), a natural pH indicator. The composite material was fabricated using a solvent casting technique. The hydrocolloids were characterized using FT-IR, SEM, UTM, XRD and water contact angle measurements. The hydrocolloids showed a good tensile strength value of about 33.9 MPa and possess antibacterial, antioxidant, and hemocompatibility properties. The hydrocolloid degraded about 79% over 7 days. The AG/SA/GN-PA showed 85% of cell viability against the L929 mouse cell line. Thus, this methodology presents cost-effectiveness, safety and a streamlined manufacturing process. Further studies were conducted to evaluate hydrocolloids as a feasible platform for practical applications in wound monitoring and healing.

Graphical abstract