A comparison of controlled release from cyclodextrin mediated and non-mediated hydrogel matrices of Moringa Oleifera gum and carboxymethyl cellulose

The present research work reported in air synthesis of a three-dimensional polymeric network of hydrogels by grafted copolymerization technique of Moringa gum and carboxymethyl cellulose by using acrylamide as a monomer, N, N-methylenebisacrylamide and ammonium persulphate as a cross-linker-initiator system. Different reaction parameters were used to optimize the synthesized hydrogel such as backbone ratio, pH of the reaction, temperature, volume of solvent, concentration of initiator, monomer and cross-linker with respect to the percentage swelling. The maximum percentage swelling 1244% was found at volume of solvent (17 mL), backbone ratio (2:1), cross-linker concentration (0.000032 molL⁻¹) and temperature (60 °C) and concentration of monomer (0.000042 molL⁻¹), and pH of 7. Mechanical strength and antibacterial properties of synthesized polymer networks are also evaluated. The confirmation of the synthesized hydrogel has been accomplished by using FTIR, FESEM, EDX, XRD, TGA and DSC characterization techniques. The synthesized hydrogels were evaluated as drug delivery carriers for in vitro release of antibiotic drug amoxicillin at pH of 2, 7 and 7.4. The drug release was compared between polymer matrices loaded with drug only and the polymer matrices loaded with Inclusion complex of β-Cyclodextrin and Amoxicillin. The controlled drug release has been found that is 99.25 ppm in 24 h in inclusion complex loaded polymer matrices, while the 75.472 ppm drug is released in just 8 h in the polymer matrices loaded directly with the drug. The Peppas-Sahlin equation holds good for release of amoxicillin at pH of 2 and 7, which further confirmed the diffusion and relaxation of polymer matrix are accountable the release of amoxicillin.