Enhanced mechanical and antimicrobial properties of hydroxypropyl methylcellulose films incorporating silver nanoparticles for wound dressing applications

In this study, we produced hydroxypropyl methylcellulose (HPMC) films containing silver nanoparticles (AgNPs) by a straightforward method for potential wound dressing applications. Polyvinylpyrrolidone (PVP) or polyvinyl alcohol (PVA) was added to these films to improve their mechanical properties. Various compositions of HPMC, PVP/PVA, and AgNPs were tested. The films containing AgNPs exhibited a yellow color, and the confirmation of silver nanoparticles was achieved through UV–Vis analysis. The antimicrobial capacity of HPMC films was assessed against strains of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans. Pristine HPMC and HPMC films blended with PVA/PVP displayed no antimicrobial activity, emphasizing the essential role of silver nanoparticles. The films with the highest AgNP content effectively inhibited Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus, surpassing the literature data. Some samples showed moderate inhibitory activity against Candida albicans. These films show potential as wound dressings, attributed to their antimicrobial properties and their convenient removal in the shower or by using a gentle water spray which may lead to reduced discomfort compared to traditional dressings. Further research is required to assess their clinical performance.