Preparation of gelatin-coated nanoliposome and application as a resveratrol delivery carrier

In the present study, nanoliposome coated with gelatin containing resveratrol (RV) was prepared to maintain its antioxidant and anticancer properties in laboratory conditions. Thin-layer method for the synthesis of nanoliposomes containing RV coated with gelatin (RGNL) and nanoliposome RV carriers was used. Fourier transform infrared spectroscopy confirmed the formation of the RGNL inclusion complex. The formulation of RV-loaded nanoliposomes showed size (79 nm). The size of the coated nanoparticles was 91 nm increased, and also, the zeta potential became more positive with increasing gelatin concentration. The encapsulation efficiency of the coated NLPs was measured to be 76.16%. The results showed that the gelatin coating stabilizes the nanoliposome and RV and reduces the release rate of RV. The cititoxicity of the nanoparticles was evaluated, the biocompatibility of the constructed system was excellent, and its cytotoxicity in breast cancer cells was significantly increased.

In the present study, liposome thin film hydration method was used to synthesize gelatin-coated liposome containing RV.