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<p>We present an asymptotic analysis of a stochastic two-compartmental cell division system with regulatory mechanisms inspired by Getto et al. (Math Biosci 245: 258–268, 2013). The hematopoietic system is modeled as a two-compartment system, where the first compartment consists of dividing cells in the bone marrow, referred to as type 0 cells, and the second compartment consists of post-mitotic cells in the blood, referred to as type 1 cells. Division and self-renewal of type 0 cells are regulated by the population density of type 1 cells. By scaling up the initial population, we demonstrate that the scaled dynamics converges in distribution to the solution of a system of ordinary differential equations (ODEs). This system of ODEs exhibits a unique non-trivial equilibrium that is globally stable. Furthermore, we establish that the scaled fluctuations of the density dynamics converge in law to a linear diffusion process with time-dependent coefficients. When the initial data is Gaussian, the limit process is a Gauss–Markov process. We analyze its asymptotic properties to elucidate the joint structure of both compartments over large times. This is achieved by proving exponential convergence in the 2-Wasserstein metric for the associated Gaussian measures on an <InlineEquation ID="IEq1"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="285_2025_2250_Article_IEq1.gif" Format="GIF" Height="16" Rendition="HTML" Resolution="72" Type="Linedraw" Width="19" /> </InlineMediaObject> <EquationSource Format="TEX">\(L^{2}\)</EquationSource> </InlineEquation> Hilbert space. Finally, we apply our results to compare the effects of regulating division and self-renewal of type 0 cells, providing insights into their respective roles in maintaining hematopoietic system stability.</p>

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Stochastic dynamics of two-compartment cell proliferation models with regulatory mechanisms for hematopoiesis

  • 期刊论文

  • 发表日期：

    2025年7月18日

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  • Ren-Yi Wang,
  • Marek Kimmel,
  • Guodong Pang

摘要

We present an asymptotic analysis of a stochastic two-compartmental cell division system with regulatory mechanisms inspired by Getto et al. (Math Biosci 245: 258–268, 2013). The hematopoietic system is modeled as a two-compartment system, where the first compartment consists of dividing cells in the bone marrow, referred to as type 0 cells, and the second compartment consists of post-mitotic cells in the blood, referred to as type 1 cells. Division and self-renewal of type 0 cells are regulated by the population density of type 1 cells. By scaling up the initial population, we demonstrate that the scaled dynamics converges in distribution to the solution of a system of ordinary differential equations (ODEs). This system of ODEs exhibits a unique non-trivial equilibrium that is globally stable. Furthermore, we establish that the scaled fluctuations of the density dynamics converge in law to a linear diffusion process with time-dependent coefficients. When the initial data is Gaussian, the limit process is a Gauss–Markov process. We analyze its asymptotic properties to elucidate the joint structure of both compartments over large times. This is achieved by proving exponential convergence in the 2-Wasserstein metric for the associated Gaussian measures on an \(L^{2}\) Hilbert space. Finally, we apply our results to compare the effects of regulating division and self-renewal of type 0 cells, providing insights into their respective roles in maintaining hematopoietic system stability.