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<p>We consider a Gatenby–Gawlinski-type model of invasive tumors in the presence of an Allee effect. We describe the construction of bistable one-dimensional traveling fronts using singular perturbation techniques in different parameter regimes corresponding to tumor interfaces with, or without, an acellular gap. By extending the front as a planar interface, we perform a stability analysis to long wavelength perturbations transverse to the direction of front propagation and derive a simple stability criterion for the front in two spatial dimensions. In particular we find that in general the presence of the acellular gap indicates transversal instability of the associated planar front, which can lead to complex interfacial dynamics such as the development of finger-like protrusions and/or different invasion speeds.</p>

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Deformations of acid-mediated invasive tumors in a model with Allee effect

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月5日

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  • Paul Carter,
  • Arjen Doelman,
  • Peter van Heijster,
  • Daniel Levy,
  • Philip Maini,
  • Erin Okey,
  • Paige Yeung

摘要

We consider a Gatenby–Gawlinski-type model of invasive tumors in the presence of an Allee effect. We describe the construction of bistable one-dimensional traveling fronts using singular perturbation techniques in different parameter regimes corresponding to tumor interfaces with, or without, an acellular gap. By extending the front as a planar interface, we perform a stability analysis to long wavelength perturbations transverse to the direction of front propagation and derive a simple stability criterion for the front in two spatial dimensions. In particular we find that in general the presence of the acellular gap indicates transversal instability of the associated planar front, which can lead to complex interfacial dynamics such as the development of finger-like protrusions and/or different invasion speeds.