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<p><i>Pseudomonas aeruginosa</i> causes life-threatening infections among patients with burn-wounds and other debilitating conditions, especially if they are resistant to carbapenem antibiotics. This study aimed to perform a genomic characterization of two multidrug-resistant <i>P. aeruginosa</i> strains (P1025 and P2279) isolated from burn patients in 2016 and 2021 in Mexico City, with a focus on the identification and characterization of their class 1 integrons. Their genomes were sequenced using combined Oxford Nanopore and Illumina technologies, and they were assigned to sequence type (ST) 309 using the PubMLST database. Their phylogenetic analysis with respect to two ST309 carbapenem resistant <i>P. aeruginosa</i> strains previously isolated in this city in 2006 showed that they are closely related. In addition, the genome of P1025 and P2279 revealed similar elements related to antibiotic resistance and both strains carry a chromosomal class 1 integron encoding resistance to β−lactams and aminoglycosides. The locus of the class 1 integron insertion in strain P2279 is identical to that observed in the two ST309 strains previously isolated in Mexico City in 2006, while the insertion of the P1025 class 1 integron represents an independent event. These findings show that carbapenem-resistant ST309 <i>P. aeruginosa</i> strains have been present in different Mexico City hospitals from 2006 to at least 2021 and might represent an important health hazard.</p>

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Extensively and Pan-Drug Resistant Pseudomonas aeruginosa Strains from Burn Patients in Mexico City are Genetically Related to Isolates Recovered a Decade Earlier in Local Hospitals

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月3日

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  • Rogelio Rojas-Rios,
  • Sara E. Quiroz-Morales,
  • Monica Dominguez-Alvarez,
  • Esaú López-Jácome,
  • Abigail González-Valdez,
  • Luis Servín-González,
  • Abigail Pérez-Valdespino,
  • Gloria Soberón-Chávez

摘要

Pseudomonas aeruginosa causes life-threatening infections among patients with burn-wounds and other debilitating conditions, especially if they are resistant to carbapenem antibiotics. This study aimed to perform a genomic characterization of two multidrug-resistant P. aeruginosa strains (P1025 and P2279) isolated from burn patients in 2016 and 2021 in Mexico City, with a focus on the identification and characterization of their class 1 integrons. Their genomes were sequenced using combined Oxford Nanopore and Illumina technologies, and they were assigned to sequence type (ST) 309 using the PubMLST database. Their phylogenetic analysis with respect to two ST309 carbapenem resistant P. aeruginosa strains previously isolated in this city in 2006 showed that they are closely related. In addition, the genome of P1025 and P2279 revealed similar elements related to antibiotic resistance and both strains carry a chromosomal class 1 integron encoding resistance to β−lactams and aminoglycosides. The locus of the class 1 integron insertion in strain P2279 is identical to that observed in the two ST309 strains previously isolated in Mexico City in 2006, while the insertion of the P1025 class 1 integron represents an independent event. These findings show that carbapenem-resistant ST309 P. aeruginosa strains have been present in different Mexico City hospitals from 2006 to at least 2021 and might represent an important health hazard.