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<p>Autism spectrum disorder (ASD) is a common childhood neurodevelopmental disorder. While many medicines offer therapeutic benefits, they are often associated with adverse side effects. Probiotics, however, present a safer interventional strategy. In this study, we investigated the effects of three probiotic agents: a multi-strain <i>Bacillus</i> formulation, a multi-strain <i>Lactobacillus</i> formulation, and the yeast <i>Saccharomyces boulardii</i>, in a rat model of ASD. The study included a total of 6 groups: a control group with no treatment, an ASD model group induced by valproate (VPA), and three probiotic intervention groups. The results showed that multi-strain <i>Bacillus</i> probiotics treatment was the most significant in alleviating VPA-induced autism in rats. Multi-strain <i>Bacillus</i> probiotics supplementation exerted a significant effect on stereotypic behaviors in ASD rats. Further studies found that multi-strain <i>Bacillus</i> probiotics alleviated ASD symptoms by reducing gut inflammation, optimizing gut microbiota composition and regulating short-chain fatty acid levels. Overall, the study evidence suggested that multi-strain <i>Bacillus</i> probiotics was the most effective for the treatment of VPA-induced ASD rat model.</p>

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Multi-strain Bacillus Probiotics has Advantages in Improving Abnormal Behavior and Intestinal Flora in Rats of Autism Spectrum Disorder

  • 期刊论文

  • 发表日期：

    2026年5月11日

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  • Qi-qi Bai,
  • Ji Chen,
  • Lu-lu Dong,
  • Mei-lin Jin,
  • Bo-kai Hu,
  • Yu Gan,
  • Chen-ye You,
  • Jing Hui

摘要

Autism spectrum disorder (ASD) is a common childhood neurodevelopmental disorder. While many medicines offer therapeutic benefits, they are often associated with adverse side effects. Probiotics, however, present a safer interventional strategy. In this study, we investigated the effects of three probiotic agents: a multi-strain Bacillus formulation, a multi-strain Lactobacillus formulation, and the yeast Saccharomyces boulardii, in a rat model of ASD. The study included a total of 6 groups: a control group with no treatment, an ASD model group induced by valproate (VPA), and three probiotic intervention groups. The results showed that multi-strain Bacillus probiotics treatment was the most significant in alleviating VPA-induced autism in rats. Multi-strain Bacillus probiotics supplementation exerted a significant effect on stereotypic behaviors in ASD rats. Further studies found that multi-strain Bacillus probiotics alleviated ASD symptoms by reducing gut inflammation, optimizing gut microbiota composition and regulating short-chain fatty acid levels. Overall, the study evidence suggested that multi-strain Bacillus probiotics was the most effective for the treatment of VPA-induced ASD rat model.