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<p><i>Lactobacilli</i> are among the most common human microbiota with several beneficial effects, such as antioxidant, anti-cancer, anti-inflammatory, and anti-proliferative activities. <i>Lactobacillus plantarum</i> (<i>L. plantarum</i>) is a micro-aerophilic, acid-tolerant, and non-spore forming <i>lactobacilli</i> with low G C content with a variety of applications in the food industry serving as a starter culture and preservative. This microorganism is among the most studied members of microbiota in terms of cancer treatment, including colorectal, breast, oral and gastric cancers, using various methods, such as animal models, cell lines, and in vitro studies. This review is focused on the studies addressing its application in various malignancies.</p>

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Lactobacillus plantarum in the Treatment of Cancers: A Review

  • 期刊论文

  • 发表日期：

    2026年3月3日

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  • Mohaddeseh Fathi,
  • Sheyda Khalilian,
  • Atefeh Bijanvand,
  • Hamid Abedinlou,
  • Soudeh Ghafouri-Fard

摘要

Lactobacilli are among the most common human microbiota with several beneficial effects, such as antioxidant, anti-cancer, anti-inflammatory, and anti-proliferative activities. Lactobacillus plantarum (L. plantarum) is a micro-aerophilic, acid-tolerant, and non-spore forming lactobacilli with low G C content with a variety of applications in the food industry serving as a starter culture and preservative. This microorganism is among the most studied members of microbiota in terms of cancer treatment, including colorectal, breast, oral and gastric cancers, using various methods, such as animal models, cell lines, and in vitro studies. This review is focused on the studies addressing its application in various malignancies.