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<p><i>Vibrio parahaemolyticus</i> is a halophilic, Gram-negative bacterium found in marine and estuarine ecosystems and is a significant contributor to seafood-related bacterial gastroenteritis. Cyclic di-GMP (c-di-GMP) is a widespread secondary messenger that modulates various cellular pathways, including virulence factor production, motility, and biofilm formation. c-di-GMP is made by diguanylate cyclases (DGCs), while its breakdown is mediated by phosphodiesterases (PDEs). Although many putative DGCs and PDEs involved in c-di-GMP metabolism have been identified in <i>V. parahaemolyticus</i>, only a few have been thoroughly studied. Furthermore, the metabolism of c-di-GMP is influenced by various environmental factors and transcriptional regulators. This review provides an overview of the c-di-GMP signaling network in <i>V. parahaemolyticus</i>, focusing on recent advancements related to c-di-GMP metabolic enzyme genes and their regulatory mechanisms. Understanding the intricate mechanisms of c-di-GMP metabolism and regulation is crucial for revealing the environmental adaptation and pathogenic strategies of <i>V. parahaemolyticus</i>.</p>

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Investigating c-di-GMP Signaling in Vibrio parahaemolyticus: Biological Effects and Mechanisms of Regulation

  • 期刊论文

  • 发表日期：

    2025年6月2日

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  • Pu Yao,
  • Yiquan Zhang,
  • Jun Ding

摘要

Vibrio parahaemolyticus is a halophilic, Gram-negative bacterium found in marine and estuarine ecosystems and is a significant contributor to seafood-related bacterial gastroenteritis. Cyclic di-GMP (c-di-GMP) is a widespread secondary messenger that modulates various cellular pathways, including virulence factor production, motility, and biofilm formation. c-di-GMP is made by diguanylate cyclases (DGCs), while its breakdown is mediated by phosphodiesterases (PDEs). Although many putative DGCs and PDEs involved in c-di-GMP metabolism have been identified in V. parahaemolyticus, only a few have been thoroughly studied. Furthermore, the metabolism of c-di-GMP is influenced by various environmental factors and transcriptional regulators. This review provides an overview of the c-di-GMP signaling network in V. parahaemolyticus, focusing on recent advancements related to c-di-GMP metabolic enzyme genes and their regulatory mechanisms. Understanding the intricate mechanisms of c-di-GMP metabolism and regulation is crucial for revealing the environmental adaptation and pathogenic strategies of V. parahaemolyticus.