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<p>This study investigated the effects of fermenting brown seaweed <i>Saccharina japonica</i> with <i>Lactobacillus brevis</i> on bioactive products’ antioxidant properties and potential anti-obesity effects. The <i>S. japonica</i> fermented by <i>L. brevis</i> (SFB) extract showed the highest ABTS scavenging activity at 3000&#xa0;μg/mL (79.3%), followed by the <i>L. brevis</i> cells (LBC) extract (68.1%) and <i>S. japonica</i> hydrolysate (SJH) extract (59.5%). At the same concentration, the DPPH radical scavenging activities of the LBC and SFB extracts were 63.2% and 68.5%, respectively, significantly higher than that of the SJH extract (38.5%). After treating cells with a 400&#xa0;μg/mL concentration for 8&#xa0;days, Oil Red O staining revealed a dose-dependent decrease in cytoplasmic lipid droplets. The lowest lipid accumulation rates were 64.2%, 55.2%, and 51.4% for SJH, LBC, and SFB, respectively. RT-qPCR results indicate reduced mRNA levels of lipid metabolism-related gene expressions. Overall, the combination of <i>S. japonica</i> and <i>L. brevis</i> fermentation has a potential application as a dietary food process for improving obesity. </p>

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Fermentation of Seaweed Saccharina japonica Using Lactobacillus brevis and its In Vitro Anti-Obesity Effects

  • 期刊论文

  • 发表日期：

    2025年4月29日

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  • Min Woo Moon,
  • Chae Hun Ra

摘要

This study investigated the effects of fermenting brown seaweed Saccharina japonica with Lactobacillus brevis on bioactive products’ antioxidant properties and potential anti-obesity effects. The S. japonica fermented by L. brevis (SFB) extract showed the highest ABTS scavenging activity at 3000 μg/mL (79.3%), followed by the L. brevis cells (LBC) extract (68.1%) and S. japonica hydrolysate (SJH) extract (59.5%). At the same concentration, the DPPH radical scavenging activities of the LBC and SFB extracts were 63.2% and 68.5%, respectively, significantly higher than that of the SJH extract (38.5%). After treating cells with a 400 μg/mL concentration for 8 days, Oil Red O staining revealed a dose-dependent decrease in cytoplasmic lipid droplets. The lowest lipid accumulation rates were 64.2%, 55.2%, and 51.4% for SJH, LBC, and SFB, respectively. RT-qPCR results indicate reduced mRNA levels of lipid metabolism-related gene expressions. Overall, the combination of S. japonica and L. brevis fermentation has a potential application as a dietary food process for improving obesity.