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<p>Although numerous novel cancer therapies have been introduced over the past five decades, cisplatin remains central to curative treatment for several major cancers, including testicular, ovarian, lung, and head and neck malignancies. The persistence of cisplatin use, despite its well-documented and often severe toxicities, constitutes a critical and unsolved paradox in oncology. Here, we examine this paradox by analyzing the economic, clinical, biological, and chemical factors that have entrenched cisplatin’s role and delayed its replacement.</p>

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Why are we still using cisplatin?

  • 期刊论文

  • 发表日期：

    2026年4月9日

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  • Jemma Arakelyan,
  • Herbert Loong,
  • Robert Peter Gale,
  • Chi-Ming Che

摘要

Although numerous novel cancer therapies have been introduced over the past five decades, cisplatin remains central to curative treatment for several major cancers, including testicular, ovarian, lung, and head and neck malignancies. The persistence of cisplatin use, despite its well-documented and often severe toxicities, constitutes a critical and unsolved paradox in oncology. Here, we examine this paradox by analyzing the economic, clinical, biological, and chemical factors that have entrenched cisplatin’s role and delayed its replacement.