Background <p>Clinical micro-skills, such as clear communication and empathetic understanding, form the foundation of every psychotherapy session. The application of these skills appears to vary not only between therapists (therapist-specific) but also within therapists (situation-specific).</p> Objective <p>This study examined the extent to which the implementation of interpersonal and communicative as well as process and time-management-related micro-skills varies between therapists and across different therapeutic situations.</p> Material and methods <p>In this study 785 response videos from 86 prospective therapists were analyzed. Participants responded to simulated patient statements as if they were the treating therapist. The videos covered various therapeutic situations (e.g., explaining a&#xa0;treatment rationale, dealing with patients’ emotions or interpersonally challenging situations) to capture the implementation of clinical micro-skills across different situations. Interpersonal and communicative as well as process and time-management-related micro-skills were assessed using the Clinical Micro-Skill Training Scale (CMST).</p> Results <p>All three skill domains were generally rated as high and showed differences both between therapists and situations.</p> Conclusion <p>The results highlight the importance of practicing clinical micro-skills in various situations during clinical training. Suitable approaches could include deliberate practice (DP) formats that enable purposeful and goal-oriented skill improvement through feedback, which could, in the future, be complemented by artificial intelligence (AI)-based systems such as Psychological Rater AI (PsyRAI).</p>