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<p>Gallbladder complications represent a significant source of morbidity in sickle cell disease, with <i>UGT1A1</i> promoter polymorphisms associated with a higher frequency of hyperbilirubinemia and cholelithiasis in affected patients and the first publications regarding this issue appeared in the literature in early 2000. There are at least three published papers providing evidence that supports this association in the Brazilian population published in 2003, 2017 and 2021. Belisário et al., very recently published a paper in <i>Annals of Hematology</i> (“Laboratory and genetic characteristics associated with gallbladder-related outcomes in sickle cell disease in Brazil: results from the REDS-III multicenter cohort study.” <i>Annals of Hematology.</i> 2026; 105(4):115) in which they claim that it is the first study in Brazilian population concerning this issue. In our opinion the previous published papers should be cited in the References, because certainly will provide readers with a more accurate and complete picture of the field´s evaluation in Brazil.</p>

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UGT1A1 polymorphisms and gallbladder-related outcomes in sickle cell disease in Brazil

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月14日

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  • Fernando Ferreira Costa,
  • Kleber Yotsumoto Fertrin

摘要

Gallbladder complications represent a significant source of morbidity in sickle cell disease, with UGT1A1 promoter polymorphisms associated with a higher frequency of hyperbilirubinemia and cholelithiasis in affected patients and the first publications regarding this issue appeared in the literature in early 2000. There are at least three published papers providing evidence that supports this association in the Brazilian population published in 2003, 2017 and 2021. Belisário et al., very recently published a paper in Annals of Hematology (“Laboratory and genetic characteristics associated with gallbladder-related outcomes in sickle cell disease in Brazil: results from the REDS-III multicenter cohort study.” Annals of Hematology. 2026; 105(4):115) in which they claim that it is the first study in Brazilian population concerning this issue. In our opinion the previous published papers should be cited in the References, because certainly will provide readers with a more accurate and complete picture of the field´s evaluation in Brazil.