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<p>Elevated body mass index (BMI) has been established as an independent risk factor for non-Hodgkin lymphoma (NHL), yet the global distribution and geographic heterogeneity of the attributable disease burden remain inadequately characterized. Drawing on data from the Global Burden of Disease study, this research examined temporal changes in disability-adjusted life years (DALYs) and deaths due to high-BMI-associated NHL from 1990 to 2021, quantified cross-national inequalities using the slope index of inequality (SII) and the concentration index (CI), and projected the burden through 2040 with an autoregressive integrated moving average model (ARIMA). The global age-standardized DALY rate (ASDR) increased from 3.45 per 100,000 in 1990 to 4.00 in 2021 and is projected to reach 4.63 by 2040; the age-standardized mortality rate (ASMR) rose from 0.13 to 0.15 per 100,000 and is expected to climb to 0.17 by 2040. Absolute inequality widened substantially, with the SII rising from 0.35 to 1.44, while the CI changed from −0.39 to −0.21, indicating a modest reduction in relative inequality but a persistent concentration of the burden in regions with a lower socio-demographic index. Both ASDR and ASMR were positively correlated with the socio-demographic index (SDI) across regions and countries. These findings demonstrate a continuously escalating global health burden of high-BMI-associated NHL with marked regional disparities, highlighting the urgent need for region-specific obesity prevention strategies and improved clinical management of NHL.</p><p>Clinical Trial: Not applicable.</p>

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Trends and projections of high body mass index-associated non-hodgkin lymphoma burden (1990–2040): A global burden of disease 2021 analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月17日

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  • Yuhao Wang,
  • Ying Li,
  • Yang Li,
  • Min Liu,
  • Lingting Zhang,
  • Xiaoyue Li,
  • Lili Tang

摘要

Elevated body mass index (BMI) has been established as an independent risk factor for non-Hodgkin lymphoma (NHL), yet the global distribution and geographic heterogeneity of the attributable disease burden remain inadequately characterized. Drawing on data from the Global Burden of Disease study, this research examined temporal changes in disability-adjusted life years (DALYs) and deaths due to high-BMI-associated NHL from 1990 to 2021, quantified cross-national inequalities using the slope index of inequality (SII) and the concentration index (CI), and projected the burden through 2040 with an autoregressive integrated moving average model (ARIMA). The global age-standardized DALY rate (ASDR) increased from 3.45 per 100,000 in 1990 to 4.00 in 2021 and is projected to reach 4.63 by 2040; the age-standardized mortality rate (ASMR) rose from 0.13 to 0.15 per 100,000 and is expected to climb to 0.17 by 2040. Absolute inequality widened substantially, with the SII rising from 0.35 to 1.44, while the CI changed from −0.39 to −0.21, indicating a modest reduction in relative inequality but a persistent concentration of the burden in regions with a lower socio-demographic index. Both ASDR and ASMR were positively correlated with the socio-demographic index (SDI) across regions and countries. These findings demonstrate a continuously escalating global health burden of high-BMI-associated NHL with marked regional disparities, highlighting the urgent need for region-specific obesity prevention strategies and improved clinical management of NHL.

Clinical Trial: Not applicable.