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<p>The <i>FUS</i>::<i>ERG</i> fusion gene is rare in patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), with a predominant prevalence in individuals of Asian descent. The incidence of AML harboring the <i>FUS</i>::<i>ERG</i> fusion gene is approximately 1%.Including the present case, a total of 154 cases have been reported in the literature to date.<i>CSF3R</i> mutation is rare in AML and frequently coexist with other genetic abnormalities to drive leukemogenesis.In this article,A case of AML harboring t(16;21)(p11.2;q22)/<i>FUS</i>::<i>ERG</i> and <i>CSF3R</i> mutations was retrospectively analyzed, with frequent identification of hemophagocytes and multinucleated cells in the bone marrow, and the relevant literature was reviewed.</p>

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AML with t(16;21)(p11.2;q22)/FUS::ERG rearrangement presenting with hemophagocytes and multinucleated cells: a case report and literature review

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  • 发表日期：

    2026年6月2日

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  • Yingying Chen,
  • XinhongYang,
  • Zhihua Zhang,
  • Xiaofeng Yang

摘要

The FUS::ERG fusion gene is rare in patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), with a predominant prevalence in individuals of Asian descent. The incidence of AML harboring the FUS::ERG fusion gene is approximately 1%.Including the present case, a total of 154 cases have been reported in the literature to date.CSF3R mutation is rare in AML and frequently coexist with other genetic abnormalities to drive leukemogenesis.In this article,A case of AML harboring t(16;21)(p11.2;q22)/FUS::ERG and CSF3R mutations was retrospectively analyzed, with frequent identification of hemophagocytes and multinucleated cells in the bone marrow, and the relevant literature was reviewed.