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<p>Myelodysplastic syndromes (MDS) and Acute Myeloid Leukemia (AML) are increasingly recognized to exhibit immune dysregulation, which can occasionally present with autoinflammatory manifestations. We describe four patients with MDS/AML harboring p53 mutations and a complex karyotype who developed inflammatory serositis without infectious correlation. All patients showed clinical improvement following corticosteroid therapy.</p>

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Serositis as possible manifestation in MDS/AML patients with complex karyotype and TP53 mutation: case series

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月2日

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  • Eleonora Gugole,
  • Edoardo Tamellini,
  • Sara Jance,
  • Nicola Serafin,
  • Pietro Antonini,
  • Chiara Colato,
  • Mauro Krampera,
  • Isacco Ferrarini,
  • Ilaria Tanasi

摘要

Myelodysplastic syndromes (MDS) and Acute Myeloid Leukemia (AML) are increasingly recognized to exhibit immune dysregulation, which can occasionally present with autoinflammatory manifestations. We describe four patients with MDS/AML harboring p53 mutations and a complex karyotype who developed inflammatory serositis without infectious correlation. All patients showed clinical improvement following corticosteroid therapy.