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<p>TDT and SCD are hereditary hemoglobinopathies that require lifelong red blood cell transfusions. Modern treatment has increased survival, exposing patients to transfusion-related problems such iron excess. Despite this movement toward an elderly patient population, transfusion-dependent adult comorbidity data is scarce, especially in Greece. A retrospective, descriptive observational analysis of 105 adult transfusion-dependent patients (92 with TDT and 13 with SCD) followed at a Greek tertiary hemoglobinopathy center in 2024 was conducted. Organ system-specific chronic comorbidities were identified from medical records. Multimorbidity distribution and comorbidity category frequencies and proportions were estimated. Mean ages were determined by comorbidity burden (≥2, ≥3, and ≥4 conditions). Means and standard deviations appear for continuous variables. Inferential analyses were avoided. All SCD patients and 84.8% of TDT patients had comorbidities. TDT most often affected other or miscellaneous illnesses (68.5%), musculoskeletal or metabolic problems (41.3%), endocrine disease (37.0%), and cardiovascular involvement (23.9%). All SCD patients had additional illnesses, 38.5% had cardiovascular problems, and 23.1% had endocrine and musculoskeletal/metabolic disorders. Multimorbidity was prevalent in both groups. Of TDT patients, 70.7% had ≥2 comorbidities, 52.2% had ≥3, and 41.3% had ≥4. SCD proportions were 92.3%, 84.6%, and 61.5%. Higher comorbidity counts were more commonly observed in older patients in both cohorts. Greek adult transfusion-dependent TDT and SCD patients have many chronic organ system comorbidities.Multimorbidity was more commonly observed in older patients, emphasizing the need for coordinated, multidisciplinary in this aging population.</p>

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Epidemiological and comorbidity burden in transfusion-dependent patients with thalassemia and sickle cell disease in Greece

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月6日

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  • Sophia Delicou,
  • Aikaterini Xydaki,
  • Vassiliki Kamposou,
  • Sabrina Goga,
  • Anthimos Papadopoulos,
  • Christina Rina,
  • Maria Moraki

摘要

TDT and SCD are hereditary hemoglobinopathies that require lifelong red blood cell transfusions. Modern treatment has increased survival, exposing patients to transfusion-related problems such iron excess. Despite this movement toward an elderly patient population, transfusion-dependent adult comorbidity data is scarce, especially in Greece. A retrospective, descriptive observational analysis of 105 adult transfusion-dependent patients (92 with TDT and 13 with SCD) followed at a Greek tertiary hemoglobinopathy center in 2024 was conducted. Organ system-specific chronic comorbidities were identified from medical records. Multimorbidity distribution and comorbidity category frequencies and proportions were estimated. Mean ages were determined by comorbidity burden (≥2, ≥3, and ≥4 conditions). Means and standard deviations appear for continuous variables. Inferential analyses were avoided. All SCD patients and 84.8% of TDT patients had comorbidities. TDT most often affected other or miscellaneous illnesses (68.5%), musculoskeletal or metabolic problems (41.3%), endocrine disease (37.0%), and cardiovascular involvement (23.9%). All SCD patients had additional illnesses, 38.5% had cardiovascular problems, and 23.1% had endocrine and musculoskeletal/metabolic disorders. Multimorbidity was prevalent in both groups. Of TDT patients, 70.7% had ≥2 comorbidities, 52.2% had ≥3, and 41.3% had ≥4. SCD proportions were 92.3%, 84.6%, and 61.5%. Higher comorbidity counts were more commonly observed in older patients in both cohorts. Greek adult transfusion-dependent TDT and SCD patients have many chronic organ system comorbidities.Multimorbidity was more commonly observed in older patients, emphasizing the need for coordinated, multidisciplinary in this aging population.