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<p>Peripheral T-cell lymphoma (PTCL) is a heterogeneous subtype of non-Hodgkin lymphoma with a poor prognosis. Red blood cell distribution width (RDW) is a hematological parameter reflecting variability in erythrocyte volume and has been associated with prognosis in various diseases. Therefore, we conducted a retrospective study on 629 newly diagnosed patients with PTCL to explore the relationship between baseline RDW, prognosis, and response to first-line treatment. The cutoff value for baseline RDW was 14.45%. Patients with baseline RDW ≥ 14.45% had a lower overall response rate than those with RDW &lt; 14.45% (41.98% vs. 78.75%, <i>P</i> &lt; 0.001). Univariate and multivariate logistic regression analyses indicated that baseline RDW ≥ 14.45% was associated with a poorer treatment response. Multivariate Cox analysis identified baseline RDW ≥ 14.45% as an independent prognostic factor in PTCL. Therefore, baseline RDW is an easily accessible and inexpensive marker for prognostic risk stratification in patients with PTCL.</p>

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Can baseline red blood cell distribution width predict outcomes in peripheral T-cell lymphoma patients?

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月23日

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  • Yifen Lan,
  • Yanchun Zhao,
  • Jianai Sun,
  • De Zhou,
  • Jinghan Wang,
  • Xiaolong Zheng,
  • Yuanfei Shi,
  • Haitao Meng,
  • Juying Wei,
  • Chunmei Yang,
  • Wenjuan Yu,
  • Jie Jin,
  • Hongyan Tong,
  • Wanzhuo Xie

摘要

Peripheral T-cell lymphoma (PTCL) is a heterogeneous subtype of non-Hodgkin lymphoma with a poor prognosis. Red blood cell distribution width (RDW) is a hematological parameter reflecting variability in erythrocyte volume and has been associated with prognosis in various diseases. Therefore, we conducted a retrospective study on 629 newly diagnosed patients with PTCL to explore the relationship between baseline RDW, prognosis, and response to first-line treatment. The cutoff value for baseline RDW was 14.45%. Patients with baseline RDW ≥ 14.45% had a lower overall response rate than those with RDW < 14.45% (41.98% vs. 78.75%, P < 0.001). Univariate and multivariate logistic regression analyses indicated that baseline RDW ≥ 14.45% was associated with a poorer treatment response. Multivariate Cox analysis identified baseline RDW ≥ 14.45% as an independent prognostic factor in PTCL. Therefore, baseline RDW is an easily accessible and inexpensive marker for prognostic risk stratification in patients with PTCL.