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<p>We report the case of a 70-year-old male with a history of <i>JAK2</i> mutation-positive post-polycythemia vera myelofibrosis and an acquired bleeding disorder. Investigations revealed platelet dysfunction, and platelet electron microscopy demonstrated an acquired gray platelet syndrome. His platelet function improved with desmopressin administration, and he successfully underwent a central venous catheter placement and hematopoietic stem cell transplant with no bleeding complications. Follow up testing demonstrated normalization of platelet function testing and resolution of his acquired gray platelet syndrome.</p>

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Acquired Gray platelet syndrome as a rare hematologic complication in a case of JAK2-positive post polycythemia Vera myelofibrosis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月2日

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  • Aishwarya Pradeep,
  • Ayo S. Falade,
  • Juliana Perez Botero,
  • Dong C. Chen,
  • Rajiv K. Pruthi,
  • Aasiya Matin

摘要

We report the case of a 70-year-old male with a history of JAK2 mutation-positive post-polycythemia vera myelofibrosis and an acquired bleeding disorder. Investigations revealed platelet dysfunction, and platelet electron microscopy demonstrated an acquired gray platelet syndrome. His platelet function improved with desmopressin administration, and he successfully underwent a central venous catheter placement and hematopoietic stem cell transplant with no bleeding complications. Follow up testing demonstrated normalization of platelet function testing and resolution of his acquired gray platelet syndrome.