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<p>Torque Teno Mini Virus (TTMV), a member of the <i>Anelloviridae</i> family, is a commensal component of the human virome. Since the initial identification of the <i>TTMV</i>::<i>RARA</i> fusion gene as a novel driver of acute promyelocytic leukemia (APL), 15 cases have been reported in retrospective studies. With advancements in diagnostic methods and increased awareness, the number of newly diagnosed cases has risen, and the clinical and molecular characteristics of <i>TTMV::RARA</i>-APL are becoming clearer. We systematically identified the clinical characteristics, fusion gene analysis, and treatment protocols of two pediatric APL patients harboring the <i>TTMV::RARA</i> fusion on this basis. While the detection of <i>TTMV::RARA</i> contributes to defining pathogenic fusion gene and MRD monitoring indicators in non-<i>PML::RARA</i>-APL cases, the precise pathogenic mechanisms of this ubiquitous symbiotic virus warrant further investigation.</p>

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Clinical features and fusion gene analysis of two Torque Teno Mini virus associated acute promyelocytic leukemia cases

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月18日

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  • Deyan Liu,
  • Jiaqi Chen,
  • Yu Luo,
  • Shu Yan,
  • Hua Nan,
  • Xue Chen,
  • Zhongyuan Lin,
  • Liejun Jiang,
  • Huihe Tang,
  • Hongyan Ma,
  • Yumeng Niu,
  • Jiancheng Fang,
  • Panxiang Cao,
  • Lili Yuan,
  • Xiaoli Ma,
  • Xiaosu Zhou,
  • Fanyong LV,
  • Yan Dai,
  • Hongxing Liu

摘要

Torque Teno Mini Virus (TTMV), a member of the Anelloviridae family, is a commensal component of the human virome. Since the initial identification of the TTMV::RARA fusion gene as a novel driver of acute promyelocytic leukemia (APL), 15 cases have been reported in retrospective studies. With advancements in diagnostic methods and increased awareness, the number of newly diagnosed cases has risen, and the clinical and molecular characteristics of TTMV::RARA-APL are becoming clearer. We systematically identified the clinical characteristics, fusion gene analysis, and treatment protocols of two pediatric APL patients harboring the TTMV::RARA fusion on this basis. While the detection of TTMV::RARA contributes to defining pathogenic fusion gene and MRD monitoring indicators in non-PML::RARA-APL cases, the precise pathogenic mechanisms of this ubiquitous symbiotic virus warrant further investigation.