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<p>Albuminuria, which depends on multiple factors, is common in patients with sickle cell disease and can progress to chronic kidney disease. In this study, we investigated the frequency and determinants of albuminuria according to sickle cell disease genotype. This multicentre cross-sectional analytical study of adults with stable sickle cell disease was conducted in Kinshasa. Genotypes were categorised as follows: homozygous, HbSS; heterozygous, HbAS; albuminuria, urinary albumin/creatinine ratio (mg/g): grade A1, &lt; 30; grade A2:30–300; or grade A3, &gt; 300. In total, 247 patients with sickle cell disease were included: 205 homozygous and 42 heterozygous. Albuminuria was prevalent in 50.5% of homozygous and 56.1% of heterozygous patients. The multivariate analysis revealed that the factors independently associated with albuminuria in the homozygous group were age ≥ 30 years (<i>p</i> = 0.037), leg ulcers (<i>p</i> = 0.010), hypertension (<i>p</i> = 0.038), and C-reactive protein level &gt; 6&#xa0;mg/L (<i>p</i> = 0.033). In the heterozygous group, only hypertension (<i>p</i> = 0.009), C-reactive protein &gt; 6&#xa0;mg/L (<i>p</i> = 0.006) and a history of vaso-occlusive crisis (<i>p</i> = 0.014) emerged as factors independent factors. More than half of patients with sickle cell disease had albuminuria, which was independently associated with hypertension and inflammation in both groups. Furthermore, there was also an association between in albuminuria and age ≥ 30 years, manifestations of vasculopathy in the homozygous group and a history of vaso-occlusive crisis in the heterozygous group.</p>

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Genotype-dependent albuminuria in adult sickle cell disease in Kinshasa

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月30日

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  • Yannick Mompango Engole,
  • Jean Robert Rissassi Makulo,
  • Justine Busanga Bukabau,
  • Yannick Mayamba Nlandu,
  • Brady Makanzu,
  • Yannick Mvita,
  • Aliocha Nkodila,
  • François Musungayi Kajingulu,
  • Vieux Momeme Mokoli,
  • Augustin Luzayadio Longo,
  • Marie France Ingole Mboliasa,
  • Clarisse Nsenga Nkondi,
  • Daddy Mbiso Liombo,
  • James Kalunga,
  • Blaise Nkolomoni,
  • Ange Ngonde,
  • Ernest Kiswaya Sumaili

摘要

Albuminuria, which depends on multiple factors, is common in patients with sickle cell disease and can progress to chronic kidney disease. In this study, we investigated the frequency and determinants of albuminuria according to sickle cell disease genotype. This multicentre cross-sectional analytical study of adults with stable sickle cell disease was conducted in Kinshasa. Genotypes were categorised as follows: homozygous, HbSS; heterozygous, HbAS; albuminuria, urinary albumin/creatinine ratio (mg/g): grade A1, < 30; grade A2:30–300; or grade A3, > 300. In total, 247 patients with sickle cell disease were included: 205 homozygous and 42 heterozygous. Albuminuria was prevalent in 50.5% of homozygous and 56.1% of heterozygous patients. The multivariate analysis revealed that the factors independently associated with albuminuria in the homozygous group were age ≥ 30 years (p = 0.037), leg ulcers (p = 0.010), hypertension (p = 0.038), and C-reactive protein level > 6 mg/L (p = 0.033). In the heterozygous group, only hypertension (p = 0.009), C-reactive protein > 6 mg/L (p = 0.006) and a history of vaso-occlusive crisis (p = 0.014) emerged as factors independent factors. More than half of patients with sickle cell disease had albuminuria, which was independently associated with hypertension and inflammation in both groups. Furthermore, there was also an association between in albuminuria and age ≥ 30 years, manifestations of vasculopathy in the homozygous group and a history of vaso-occlusive crisis in the heterozygous group.