Scholarlink

<p>Chronic myeloid leukemia in the blast phase (B<i>P-</i>CML) remains challenging despite advancements in tyrosine kinase inhibitors (TKIs). This study retrospectively assessed B<i>P-</i>CML patients who underwent allogeneic stem cell transplantation (allo-SCT) from June 2009 to December 2022. Thirty-three patients were included and the median age was 41 years, with a predominantly male cohort. Myeloablative conditioning and peripheral blood stem cells were used in the majority of the patients. The estimated 2-year overall survival (OS) was 48.3% of the cohort. Relapse occurred in 48.5% of patients, typically within 3 months post-transplant. Post-transplant TKI maintenance showed a significant association with improved OS (<i>p-</i>value = 0.001). The study highlights the need for early intervention and optimized post-transplant maintenance to improve outcomes.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Allogeneic transplantation for CML blast phase: Learnings over last decade from a single centre in North India

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年4月15日

查看全文
  • Pritish Chandra Patra,
  • Sujay Rainchwar,
  • Reema Singh,
  • Niharika Bhatia,
  • Sakshi Bhatnagar,
  • Roy J. Palatty,
  • Nakul Tikare,
  • Tribikram Panda,
  • Vipul Sharad Sheth,
  • Narendra Agrawal,
  • Rohan Halder,
  • Dinesh Bhurani

摘要

Chronic myeloid leukemia in the blast phase (BP-CML) remains challenging despite advancements in tyrosine kinase inhibitors (TKIs). This study retrospectively assessed BP-CML patients who underwent allogeneic stem cell transplantation (allo-SCT) from June 2009 to December 2022. Thirty-three patients were included and the median age was 41 years, with a predominantly male cohort. Myeloablative conditioning and peripheral blood stem cells were used in the majority of the patients. The estimated 2-year overall survival (OS) was 48.3% of the cohort. Relapse occurred in 48.5% of patients, typically within 3 months post-transplant. Post-transplant TKI maintenance showed a significant association with improved OS (p-value = 0.001). The study highlights the need for early intervention and optimized post-transplant maintenance to improve outcomes.