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<p>There has been a growing concern regarding the adverse events including hematological malignancies which occurring in the later stages following CAR-T immunotherapy. Here, we presented a case of secondary MDS/AML following CAR-T immunotherapy in our center. This refractory/relapsed MM patient who received systematic treatment including chemotherapy and targeted drug as well as autologous stem cell transplantation was developed into MDS and AML especially after BCMA CAR-T immunotherapy, and even allogeneic hematopoietic stem cell transplantation could not save the very poor prognosis. Further meta-analysis also demonstrated the considerable heterogeneity through the total studies CD19 and BCMA CAR-T subgroups. In conclusion, it is imperative that long-term and close monitoring for patients undergoing CAR-T immunotherapy, with particular attention to the potential development of hematological malignancies.</p>

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Therapy related acute myeloid leukemia secondary to CAR-T therapy in refractory/relapsed multiple myeloma patient showing poor prognosis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月31日

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  • Ran An,
  • Weiying Bao,
  • Zeying Yan,
  • Haimin Sun,
  • Xiaoqian Xu,
  • Sujiang Zhang

摘要

There has been a growing concern regarding the adverse events including hematological malignancies which occurring in the later stages following CAR-T immunotherapy. Here, we presented a case of secondary MDS/AML following CAR-T immunotherapy in our center. This refractory/relapsed MM patient who received systematic treatment including chemotherapy and targeted drug as well as autologous stem cell transplantation was developed into MDS and AML especially after BCMA CAR-T immunotherapy, and even allogeneic hematopoietic stem cell transplantation could not save the very poor prognosis. Further meta-analysis also demonstrated the considerable heterogeneity through the total studies CD19 and BCMA CAR-T subgroups. In conclusion, it is imperative that long-term and close monitoring for patients undergoing CAR-T immunotherapy, with particular attention to the potential development of hematological malignancies.