<p>A comprehensive analysis of crop water footprint (WFP), water use efficiency (WUE) and economic water productivity (EWP) between 2010 and 2020 in two climatically and economically diverse agricultural regions: Punjab, Pakistan and Western Australia, Australia was undertaken. Using the Water Footprint Network method and climate, soil and agricultural production data, the study quantified green, blue and grey water footprints for five staple crops in each region. Normalization by local water scarcity and irrigation share was used to compare between the two regions with different water stress levels and irrigation dependence. Results showed that the total crop water requirements in Punjab increased by 12% during the study period due to changing climatic conditions. Cotton and rice had the highest WFP and dependence on irrigation, however generated relatively low economic returns per unit of water, showcasing inefficiency in the current agricultural system. In contrast, rain-fed crops in WA showed lower absolute crop water requirements and lower increases in normalized WFP, with stable WUE and EWP with cereals, showcasing efficient water use under climate-driven limitations. Normalization highlighted the difference in water stress, identifying that Punjab’s irrigation-intensive crops put much greater stress on local water resources than WA crops. Integration of biophysical and economic indicators, when normalizing for water scarcity, provides a strong basis to assess water practice of various agricultural systems. The results indicate the necessity for location-specific approaches: increased irrigation efficiency and suitable crop selection in Punjab; and climate-resilient cropping to maximize water use productivity and economic return in WA.</p>