Purpose <p>This study evaluated the safety and efficacy of radiofrequency ablation for the palliative treatment of bone metastases in the SPARTA study.</p> Materials and Methods <p>The SPINERY® Radiofrequency Ablation (RFA) System Premarket Study (SPARTA) is a prospective, single-arm, multicenter clinical trial in Italy. Patients with metastatic bone tumors underwent RFA using SPINERY® between July 2022 and December 2023. The Brief Pain Inventory (BPI) for pain severity and the EQ-5D-5L questionnaire for quality of life (QoL) were assessed at baseline and at 1, 3, and 12&#xa0;months post-procedure. Primary endpoints were achievement of a ≥ 2-point reduction in the 3-month BPI score, and completion of the procedure without device-related adverse events.</p> Results <p>Among 52 enrolled patients (mean age 63.8 ± 11.2, 61.5% [32/52] female), RFA was performed in 51, followed by vertebroplasty in 78.4% (40/51), with 100% technical success and no device-related adverse events. Compared to baseline, mean BPI scores improved at 1 month (Δ− 3.3 ± 2.7, <i>p</i> &lt; 0.001), 3 months (Δ− 4.2 ± 2.5, <i>p</i> &lt; 0.001), and 12 months (Δ− 5.4 ± 2.7, <i>p</i> &lt; 0.001). Mean EQ-5D-5L scores also improved at 1 month (Δ15.7 ± 17.6, <i>p</i> &lt; 0.001), 3 months (Δ22.7 ± 17.1, <i>p</i> &lt; 0.001), and 12 months (Δ33.3 ± 20.7, <i>p</i> &lt; 0.001). There were 13 (25.5%) adverse events and 13 (25.5%) deaths that were disease-related, not device-related.</p> Conclusion <p>The SPARTA study demonstrates rapid and substantial pain relief within 1&#xa0;month and improved QOL, supporting radiofrequency ablation, in combination with vertebroplasty when indicated, as a minimally invasive treatment for pain associated with bone metastases.</p> Level of Evidence 3 <p>Prospective cohort study</p> Graphical Abstract <p></p>