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Purpose <p>This study examines the efficacy of genicular artery embolization (GAE) as a treatment to reduce chronic knee&#xa0;pain in patients who have previously undergone total knee arthroplasty (TKA).</p> Materials and Methods <p>Thirty-seven consecutive patients (13 men and 24 women) with a history of persistent pain for at least one year after TKA underwent GAE at a single center. The mean age across all patients was 72.8 ± 9.7&#xa0;years, and the mean BMI was 29.3 ± 6.1&#xa0;kg/m<sup>2</sup>. Imipenem cilastatin particles and/or microspheres were delivered through a microcatheter to the targeted arteries by a board-certified interventional cardiologist. Clinical success was determined by degree of improvement in patient response to the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Visual Analog Scale (VAS) pain questionnaires at one-month and three-month intervals following successful embolization of targeted arteries.</p> Results <p>Among 37 patients, WOMAC scores at the preliminary, one-month, and three-month follow-up appointments were 64% ± 6%, 39% ± 8%, and 36% ± 8%, respectively (95% CI). VAS scores were 8.1 ± 0.6, 3.2 ± 1.1, and 3.1 ± 1.0 (95% CI). A paired t-test showed a statistically significant improvement at both one-month and three-month post-procedure evaluations. (p &lt; 0.05). Overall, 64.9% (n = 24) of patients achieved at least a 50% improvement in pain scores by the end of the study term.</p> Conclusion <p>GAE shows efficacy as an adjunct treatment in patients with TKA and long-standing pain (&gt; 1&#xa0;year). Further research is needed to assess long-term outcomes and broader applicability.</p> Graphical Abstract <p></p>

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Genicular Artery Embolization as a Treatment Option for Refractory Knee Pain Post Total Knee Arthroplasty: A Prospective Series

  • 期刊论文

  • 发表日期：

    2026年1月8日

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  • Nishanth Konduru,
  • Anton Hnatov,
  • Samuel Pravin Joshua,
  • Merna Metry,
  • Hardayal Singh,
  • Siddhartha Rao

摘要

Purpose

This study examines the efficacy of genicular artery embolization (GAE) as a treatment to reduce chronic knee pain in patients who have previously undergone total knee arthroplasty (TKA).

Materials and Methods

Thirty-seven consecutive patients (13 men and 24 women) with a history of persistent pain for at least one year after TKA underwent GAE at a single center. The mean age across all patients was 72.8 ± 9.7 years, and the mean BMI was 29.3 ± 6.1 kg/m2. Imipenem cilastatin particles and/or microspheres were delivered through a microcatheter to the targeted arteries by a board-certified interventional cardiologist. Clinical success was determined by degree of improvement in patient response to the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Visual Analog Scale (VAS) pain questionnaires at one-month and three-month intervals following successful embolization of targeted arteries.

Results

Among 37 patients, WOMAC scores at the preliminary, one-month, and three-month follow-up appointments were 64% ± 6%, 39% ± 8%, and 36% ± 8%, respectively (95% CI). VAS scores were 8.1 ± 0.6, 3.2 ± 1.1, and 3.1 ± 1.0 (95% CI). A paired t-test showed a statistically significant improvement at both one-month and three-month post-procedure evaluations. (p < 0.05). Overall, 64.9% (n = 24) of patients achieved at least a 50% improvement in pain scores by the end of the study term.

Conclusion

GAE shows efficacy as an adjunct treatment in patients with TKA and long-standing pain (> 1 year). Further research is needed to assess long-term outcomes and broader applicability.

Graphical Abstract