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<p>Renal cell carcinoma (RCC) is the most common type of kidney cancer and accounts for approximately 90% of all renal malignancies. About 30% of patients have metastatic disease at their initial presentation. Historically, these patients have very poor prognosis with a median survival of 12 months. The recent introduction of immune checkpoint inhibitors (ICI)-based immunotherapy, which disrupts cancer-induced immune tolerance and promotes immune-mediated cancer cell killing, has significantly improved patient outcome. While ICI-based therapy represents the standard of care for metastatic RCC, there are significant treatment-related adverse effects. This review article will examine how image-guided ablation, as an adjunct to immunotherapy, can improve survival and quality of life in patients with metastatic RCC.</p>

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Beyond the Scalpel: the Role of Image-Guided Thermal Ablation in Management of Metastatic Renal Cell Carcinoma in the Era of Immunotherapy

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月24日

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  • Kin Fen Kevin Fung,
  • Philippe Barthelemy,
  • Fabien Moinard-Butot,
  • Mathilde Airoldi,
  • Roberto Luigi Cazzato,
  • Afshin Gangi

摘要

Renal cell carcinoma (RCC) is the most common type of kidney cancer and accounts for approximately 90% of all renal malignancies. About 30% of patients have metastatic disease at their initial presentation. Historically, these patients have very poor prognosis with a median survival of 12 months. The recent introduction of immune checkpoint inhibitors (ICI)-based immunotherapy, which disrupts cancer-induced immune tolerance and promotes immune-mediated cancer cell killing, has significantly improved patient outcome. While ICI-based therapy represents the standard of care for metastatic RCC, there are significant treatment-related adverse effects. This review article will examine how image-guided ablation, as an adjunct to immunotherapy, can improve survival and quality of life in patients with metastatic RCC.