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<p>Hydrophilic polymer embolization (HPE) represents a complication of endovascular interventions, occurring when the hydrophilic coating detaches, eventually causing distal ischemia and/or inflammation. We conducted a scoping review using PubMed, providing a summary of the main clinical implications potentially related to HPE. The analysis primarily found case reports/series (n = 48/56), suggesting that this event is perceived as sporadic. However, the potentially subtle presentation of HPE and a limited understanding of this condition among medical professionals are likely to contribute to its underrepresentation in medical literature. To better understand HPE risks, a detailed device analysis considering material and coating variations is crucial. Collaboration among manufacturers, clinicians, and regulators is needed to improve safety, diagnostics, and patient outcomes, bridging knowledge gaps and addressing this complex issue effectively.</p> Graphical Abstract <p></p>

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Hydrophilic Polymer Embolism: An Underappreciated Complication of Endovascular Procedures that Physicians Should be Aware Of

  • 期刊论文

  • 发表日期：

    2025年6月20日

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  • Marco Parillo,
  • Robert P. Wawer Matos Reimer,
  • Carlo A. Mallio,
  • Peter Reimer,
  • Aart J. van der Molen

摘要

Hydrophilic polymer embolization (HPE) represents a complication of endovascular interventions, occurring when the hydrophilic coating detaches, eventually causing distal ischemia and/or inflammation. We conducted a scoping review using PubMed, providing a summary of the main clinical implications potentially related to HPE. The analysis primarily found case reports/series (n = 48/56), suggesting that this event is perceived as sporadic. However, the potentially subtle presentation of HPE and a limited understanding of this condition among medical professionals are likely to contribute to its underrepresentation in medical literature. To better understand HPE risks, a detailed device analysis considering material and coating variations is crucial. Collaboration among manufacturers, clinicians, and regulators is needed to improve safety, diagnostics, and patient outcomes, bridging knowledge gaps and addressing this complex issue effectively.

Graphical Abstract