Scholarlink

Purpose <p>To evaluate the safety and clinical outcomes of genicular artery embolization for knee osteoarthritis (OA).</p> Materials and Methods <p>A total of 43 patients suffering from osteoarthritis of the knee (Kellgren and Lawrence grades 2–4) were included in this prospective study. Peri-interventional data including vascular access, embolized target vessels, fluoroscopy time and radiation dose were collected. After 2-, 3- and 12-month pain scores, functional outcomes and adverse events were assessed through a standardized questionnaire.</p> Results <p>All embolizations were performed via a coaxial system consisting of a 4F Cobra catheter and a Microcatheter without the use of an introducer sheath. A mixture of contrast agent (Accupaque, GE, USA) and microspheres (Embosphere, Merit Medical, USA) was injected. At least three genicular branches were embolized per patient with following incidence: inferior lateral genicular artery (77%), superior lateral genicular artery (74%) and descending genicular artery (74%). The mean total volume of permanent embolic agent used was 3.6 ± 1.3&#xa0;ml. The average fluoroscopy time was 29 ± 11&#xa0;min, and radiation dose was 40.84 ± 26.21&#xa0;Gy/cm<sup>2</sup>. During the 1-year follow-up, patients pain while walking showed an average reduction of 2.0 ± 0.5 points on the numeric rating scale (<i>p</i> &lt; 0.0001), without any significant difference between different grades of osteoarthritis. Besides mild transient skin discolorations in four patients, no complications were observed.</p> Conclusion <p>Embolization of multiple genicular artery branches in a single session using microspheres in averaged doses higher than 2&#xa0;ml total is safe and effective in reducing pain and improving functionality in patients with symptomatic OA, regardless of severity grade.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Genicular Artery Embolization in Moderate to Severe Knee Osteoarthritis: Technique, Safety and Clinical Outcome

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年2月19日

查看全文
  • A. Taheri Amin,
  • I. Frommhold,
  • A. Huebner,
  • M. Boschheidgen,
  • M. Frenken,
  • K. Jannusch,
  • E. Tietz,
  • D. Weiss,
  • L. M. Wilms,
  • F. Ziayee,
  • P. Minko

摘要

Purpose

To evaluate the safety and clinical outcomes of genicular artery embolization for knee osteoarthritis (OA).

Materials and Methods

A total of 43 patients suffering from osteoarthritis of the knee (Kellgren and Lawrence grades 2–4) were included in this prospective study. Peri-interventional data including vascular access, embolized target vessels, fluoroscopy time and radiation dose were collected. After 2-, 3- and 12-month pain scores, functional outcomes and adverse events were assessed through a standardized questionnaire.

Results

All embolizations were performed via a coaxial system consisting of a 4F Cobra catheter and a Microcatheter without the use of an introducer sheath. A mixture of contrast agent (Accupaque, GE, USA) and microspheres (Embosphere, Merit Medical, USA) was injected. At least three genicular branches were embolized per patient with following incidence: inferior lateral genicular artery (77%), superior lateral genicular artery (74%) and descending genicular artery (74%). The mean total volume of permanent embolic agent used was 3.6 ± 1.3 ml. The average fluoroscopy time was 29 ± 11 min, and radiation dose was 40.84 ± 26.21 Gy/cm2. During the 1-year follow-up, patients pain while walking showed an average reduction of 2.0 ± 0.5 points on the numeric rating scale (p < 0.0001), without any significant difference between different grades of osteoarthritis. Besides mild transient skin discolorations in four patients, no complications were observed.

Conclusion

Embolization of multiple genicular artery branches in a single session using microspheres in averaged doses higher than 2 ml total is safe and effective in reducing pain and improving functionality in patients with symptomatic OA, regardless of severity grade.

Graphical Abstract