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Introduction <p>Acne vulgaris (AV) is one of the most common dermatological conditions, affecting over 85% of adolescents and a wide range of young adults. Beyond its cosmetic impact, acne can cause significant psychological and quality of life (QoL) issues, highlighting the importance of patient-reported outcome measures (PROMs). The primary aim of this study was to translate, culturally adapt, and validate the Italian version of the ACNE-Q questionnaire, a disease-specific PROM for acne. The secondary aim was to evaluate the effectiveness of the ACNE-FREE protocol in patients with mild-to-moderate facial acne, using the validated Italian ACNE-Q.</p> Methods <p>This prospective study involved 54 patients with mild-to-moderate facial acne treated with the ACNE-FREE protocol. The Italian translation and validation of ACNE-Q followed a rigorous process of forward translation, back-translation, review and patient interviews. Patients completed the ACNE-Q at baseline (T0), after 3 months (T1), and after 6 months (T2). Outcome changes were analyzed with ANOVA test (Prism software).</p> Results <p>The mean age of participants was 25.04 ± 4.23 years, with 39 females and 11 males. All ACNE-Q scale scores demonstrated significant improvements over time, showing reductions in “Symptoms” and “Appearance-related distress” scores (p&lt;0.05), indicating a decrease in symptoms and psychological impact. The “Facial Skin” scale showed an increase in scores, suggestive of clinical improvement. The data support the efficacy of the ACNE-FREE protocol in improving both clinical outcomes and patient QoL.</p> Conclusions <p>The ACNE-Q is a reliable and valid tool for assessing patient-reported outcomes in Italian-speaking populations with acne. The ACNE-FREE treatment protocol yielded significant improvements in skin condition and psychosocial parameters, enhancing overall quality of life. An integrated approach addressing both physical symptoms and psychological well-being is essential for optimal acne management.</p> Level of Evidence IV <p>This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors <a href="http://www.springer.com/00266">www.springer.com/00266</a>.</p>

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Italian Translation, Cultural Adaptation and Clinical Application of the ACNE-Q: Patient-Reported Outcome Measure in Mild-to-Moderate Facial Acne

  • 期刊论文

  • 发表日期：

    2026年5月18日

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  • Annalisa Cogliandro,
  • Marco Gratteri,
  • Caterina Dianzani,
  • Giovanni Francesco Marangi,
  • Riccardo De Bernardis,
  • Gaia De Angelis,
  • Roberta Romano,
  • Claudio Conforti,
  • Francesco Gratteri,
  • Paolo Persichetti

摘要

Introduction

Acne vulgaris (AV) is one of the most common dermatological conditions, affecting over 85% of adolescents and a wide range of young adults. Beyond its cosmetic impact, acne can cause significant psychological and quality of life (QoL) issues, highlighting the importance of patient-reported outcome measures (PROMs). The primary aim of this study was to translate, culturally adapt, and validate the Italian version of the ACNE-Q questionnaire, a disease-specific PROM for acne. The secondary aim was to evaluate the effectiveness of the ACNE-FREE protocol in patients with mild-to-moderate facial acne, using the validated Italian ACNE-Q.

Methods

This prospective study involved 54 patients with mild-to-moderate facial acne treated with the ACNE-FREE protocol. The Italian translation and validation of ACNE-Q followed a rigorous process of forward translation, back-translation, review and patient interviews. Patients completed the ACNE-Q at baseline (T0), after 3 months (T1), and after 6 months (T2). Outcome changes were analyzed with ANOVA test (Prism software).

Results

The mean age of participants was 25.04 ± 4.23 years, with 39 females and 11 males. All ACNE-Q scale scores demonstrated significant improvements over time, showing reductions in “Symptoms” and “Appearance-related distress” scores (p<0.05), indicating a decrease in symptoms and psychological impact. The “Facial Skin” scale showed an increase in scores, suggestive of clinical improvement. The data support the efficacy of the ACNE-FREE protocol in improving both clinical outcomes and patient QoL.

Conclusions

The ACNE-Q is a reliable and valid tool for assessing patient-reported outcomes in Italian-speaking populations with acne. The ACNE-FREE treatment protocol yielded significant improvements in skin condition and psychosocial parameters, enhancing overall quality of life. An integrated approach addressing both physical symptoms and psychological well-being is essential for optimal acne management.

Level of Evidence IV

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.