Scholarlink

Background <p>Localized adiposity remains a significant clinical challenge. Combined shockwave and ultrasound therapy has emerged as a promising non-invasive approach, but its synergistic mechanisms and clinical efficacy require comprehensive evaluation. This systematic review aims to synthesize evidence for this combined therapy, with focus on the novel dual-action axis model.</p> Methods <p>A comprehensive search (2015-2025) was conducted following PRISMA guidelines. Thirty-one studies (n = 2,758 participants) were included. Methodological quality was assessed using ROBIS, AMSTAR 2, and RoB 2 tools. Data were synthesized narratively and with meta-analysis where appropriate.</p> Results <p>The dual-action axis model identified mechanical effects (cavitation, Piezo1 activation) and thermal effects (hyperthermia, TRPV4-mediated thermogenesis). Key mechanisms included Piezo1 activation (32 ± 5% increase in adipocyte apoptosis) and TRPV4 stimulation (1.8-fold mitochondrial activity). Meta-analysis showed significant fat reduction across areas: abdomen (2.1 cm, 95% CI 1.7-2.5), thighs (1.8 cm, 1.5-2.1). Combined therapy was superior to cryolipolysis at 6 months (2.3 cm vs 1.5 ± 0.8 cm, p = 0.008) but had higher 12-month recurrence (23% vs 8.7%, p &lt; 0.001). Safety profile was favorable (severe adverse events &lt; 1%).</p> Conclusion <p>Combined therapy achieves synergistic fat reduction through Piezo1/TRPV4 mechanisms. While superior to cryolipolysis short-term, maintenance strategies are needed. This approach represents a paradigm shift in non-invasive body contouring.</p> No Level Assigned <p>This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors <a href="http://www.springer.com/00266">www.springer.com/00266</a></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Synergistic Mechanisms and Clinical Efficacy of Combined Shockwave and Ultrasound Therapy for Localized Adiposity: A Systematic Review and Meta-Analysis of 31 Studies

  • 期刊论文

  • 发表日期：

    2026年5月8日

查看全文
  • Qiong Wu,
  • Wenting Zhao,
  • Qin Liu,
  • Bin Huang,
  • Ying Xiao,
  • Minzhi Yang,
  • Fangfang Li,
  • Huan Du

摘要

Background

Localized adiposity remains a significant clinical challenge. Combined shockwave and ultrasound therapy has emerged as a promising non-invasive approach, but its synergistic mechanisms and clinical efficacy require comprehensive evaluation. This systematic review aims to synthesize evidence for this combined therapy, with focus on the novel dual-action axis model.

Methods

A comprehensive search (2015-2025) was conducted following PRISMA guidelines. Thirty-one studies (n = 2,758 participants) were included. Methodological quality was assessed using ROBIS, AMSTAR 2, and RoB 2 tools. Data were synthesized narratively and with meta-analysis where appropriate.

Results

The dual-action axis model identified mechanical effects (cavitation, Piezo1 activation) and thermal effects (hyperthermia, TRPV4-mediated thermogenesis). Key mechanisms included Piezo1 activation (32 ± 5% increase in adipocyte apoptosis) and TRPV4 stimulation (1.8-fold mitochondrial activity). Meta-analysis showed significant fat reduction across areas: abdomen (2.1 cm, 95% CI 1.7-2.5), thighs (1.8 cm, 1.5-2.1). Combined therapy was superior to cryolipolysis at 6 months (2.3 cm vs 1.5 ± 0.8 cm, p = 0.008) but had higher 12-month recurrence (23% vs 8.7%, p < 0.001). Safety profile was favorable (severe adverse events < 1%).

Conclusion

Combined therapy achieves synergistic fat reduction through Piezo1/TRPV4 mechanisms. While superior to cryolipolysis short-term, maintenance strategies are needed. This approach represents a paradigm shift in non-invasive body contouring.

No Level Assigned

This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266