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Background <p>In this study, we conducted a randomized controlled clinical trial to investigate the effectiveness and safety of punch excision versus manual fractional technology (MFT) in patients undergoing intralesional triamcinolone acetonide and 5-fluorouracil injection.</p> Methods <p>Patients with keloid were randomly divided into two groups: One received punch excision combined with intralesional triamcinolone acetonide and 5-fluorouracil injection (punch excision + TAC&amp;5-FU), and the other received MFT combined with intralesional triamcinolone acetonide and 5-fluorouracil injection (MFT + TAC&amp;5-FU). Designed treatments and regular evaluations were conducted.</p> Results <p>The significant improvement was observed in both groups. Regarding the effectiveness of different combined therapies, MFT combined with TAC&amp;5-FU demonstrated a greater improvement of mVSS, POSAS, and DLQI without statistical differences when comparing with those of punch excision combined therapy. Likewise, the injection times and adverse events were generally similar across both groups.</p> Conclusion <p>This study demonstrated that punch excision combined with TAC&amp;5-FU, as well as MFT combined with TAC&amp;5-FU, was promising therapeutic options for keloids without a notable difference in effectiveness and safety.</p> Level of Evidence I <p>A single-blinded randomized clinical trial. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors <a href="http://www.springer.com/00266">www.springer.com/00266</a>.</p>

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Comparing Punch Excision Combined with Triamcinolone Acetonide and 5-Fluorouracil Injection and Manual Fractional Technology Combined with Triamcinolone Acetonide and 5-Fluorouracil Injection in Keloids: A Single-Blinded Randomized Clinical Trial

  • 期刊论文

  • 发表日期：

    2026年3月16日

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  • Xianzhong Zhu,
  • Yurui Han,
  • Peijun Mai,
  • Yanghai Wei,
  • Yiran Qiu,
  • Jiawen Yin,
  • Ying Zhang,
  • Jin Su,
  • Wenlin Yang,
  • Qing Qi

摘要

Background

In this study, we conducted a randomized controlled clinical trial to investigate the effectiveness and safety of punch excision versus manual fractional technology (MFT) in patients undergoing intralesional triamcinolone acetonide and 5-fluorouracil injection.

Methods

Patients with keloid were randomly divided into two groups: One received punch excision combined with intralesional triamcinolone acetonide and 5-fluorouracil injection (punch excision + TAC&5-FU), and the other received MFT combined with intralesional triamcinolone acetonide and 5-fluorouracil injection (MFT + TAC&5-FU). Designed treatments and regular evaluations were conducted.

Results

The significant improvement was observed in both groups. Regarding the effectiveness of different combined therapies, MFT combined with TAC&5-FU demonstrated a greater improvement of mVSS, POSAS, and DLQI without statistical differences when comparing with those of punch excision combined therapy. Likewise, the injection times and adverse events were generally similar across both groups.

Conclusion

This study demonstrated that punch excision combined with TAC&5-FU, as well as MFT combined with TAC&5-FU, was promising therapeutic options for keloids without a notable difference in effectiveness and safety.

Level of Evidence I

A single-blinded randomized clinical trial. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.