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Background <p>This study aimed to evaluate the efficacy and biocompatibility of various absorbable threads from Hans BioMed for facial lifting in a Sprague Dawley rat model, focusing on collagen production, inflammatory responses, and overall skin remodeling.</p> Methods <p>Six types of absorbable threads, PCL, PDO, PDLLA, PLCL, and two P4HB variants (55 and 90% elongation) from Hans BioMed, were analyzed using histological, immunohistochemical, and molecular methods for observation, including 1, 2, 4, and 8&#xa0;weeks post-thread insertion. Total 140 rats were used with 20 rats for each thread group, in which five rats for each time point.</p> Results <p>Firstly, inflammatory markers, including TNF-<i>α</i> and IL-6, peaked at 1&#xa0;week and subsided significantly by 8&#xa0;weeks, confirming the safety profile of all threads. The overall results demonstrated that all threads induced collagen formation and reduced inflammation over time. Notably, collagen 1 levels in all testing groups steadily increased from 2 to 8&#xa0;weeks, complemented by reduced metalloproteinase expression, indicating preserved collagen stability, observed in Western Blotting. Additionally, RT-PCR highlighted increased expression of collagen-related genes and elevated TGF-<i>β</i> and <i>α</i>-SMA levels, suggesting enhanced skin remodeling capabilities.</p> Conclusion <p>All tested absorbable threads promoted collagen formation and showed minimal response to inflammation over time. The findings provide a foundation for developing advanced thread-lifting products, offering improved skin elasticity, firmness, and collagen synthesis outcomes.</p> No Level Assigned <p>This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors <a href="https://link.springer.com/journal/00266">https://link.springer.com/journal/00266</a>.</p> Graphical Abstract <p></p>

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Comparative Analysis of Collagen Induction in Sprague Dawley Rat Model Using Absorbable Threads for Facial Lifting and Rejuvenation

  • 期刊论文

  • 发表日期：

    2025年12月23日

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  • Linh Thi Thuy Le,
  • Nguyen Ngan Giang,
  • Thuy-Tien Thi Trinh,
  • Pham Thi Nga,
  • Xin Rui Zhang,
  • Yong Xun Jin,
  • Daeun Seo,
  • Dong Keon Lee,
  • Sihyeon Park,
  • Pham Ngoc Chien,
  • Chan Yeong Heo

摘要

Background

This study aimed to evaluate the efficacy and biocompatibility of various absorbable threads from Hans BioMed for facial lifting in a Sprague Dawley rat model, focusing on collagen production, inflammatory responses, and overall skin remodeling.

Methods

Six types of absorbable threads, PCL, PDO, PDLLA, PLCL, and two P4HB variants (55 and 90% elongation) from Hans BioMed, were analyzed using histological, immunohistochemical, and molecular methods for observation, including 1, 2, 4, and 8 weeks post-thread insertion. Total 140 rats were used with 20 rats for each thread group, in which five rats for each time point.

Results

Firstly, inflammatory markers, including TNF-α and IL-6, peaked at 1 week and subsided significantly by 8 weeks, confirming the safety profile of all threads. The overall results demonstrated that all threads induced collagen formation and reduced inflammation over time. Notably, collagen 1 levels in all testing groups steadily increased from 2 to 8 weeks, complemented by reduced metalloproteinase expression, indicating preserved collagen stability, observed in Western Blotting. Additionally, RT-PCR highlighted increased expression of collagen-related genes and elevated TGF-β and α-SMA levels, suggesting enhanced skin remodeling capabilities.

Conclusion

All tested absorbable threads promoted collagen formation and showed minimal response to inflammation over time. The findings provide a foundation for developing advanced thread-lifting products, offering improved skin elasticity, firmness, and collagen synthesis outcomes.

No Level Assigned

This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors https://link.springer.com/journal/00266.

Graphical Abstract