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Background <p>Poly(D,L-lactic acid) (PDLLA) is increasingly used for skin rejuvenation, utilizing innovative delivery systems like needle-free injectors to enhance patient comfort and efficacy.</p> Objective <p>To evaluate the clinical efficacy and safety of PDLLA delivered through a microjet injector and to assess the durability of its rejuvenating effect over 24 weeks.</p> Methods <p>This study involved 40 patients who underwent five treatment sessions of PDLLA&#xa0;(Juvelook) treatment via a needle-free microjet system. Efficacy was assessed through clinical evaluation (GAIS), patient satisfaction surveys, and 3D imaging analysis at baseline, 8 weeks, and 24 weeks.</p> Results <p>GAIS scores improved from 1.48 ± 0.32 at baseline to 1.90 ± 0.28 at 8 weeks and 2.16 ± 0.26 at 24 weeks (<i>p</i> &lt; 0.001). Patient satisfaction increased from 3.38 ± 1.12 to 7.95 ± 0.86 (8 weeks) and 8.71 ± 0.69 (24 weeks). 3D imaging showed progressive vector displacement, with a mean displacement of 1.5 ± 0.4 mm at 8 weeks and 2.3 ± 0.5 mm at 24 weeks, indicating sustained lifting and textural improvement. These effects are attributed to the high-velocity microjet delivery mechanism, which enables uniform intradermal dispersion with minimal trauma.</p> Conclusion <p>PDLLA&#xa0;(Juvelook) delivered via needle-free injection (CUREJET, BAZ&#xa0;BIOMEDIC&#xa0;CO., LTD.) is a safe and effective modality for facial rejuvenation, offering a promising alternative to conventional methods. Further research is needed to explore long-term outcomes and mechanistic insights.</p> Level of Evidence IV <p>This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors <a href="http://www.springer.com/00266">www.springer.com/00266</a>.</p>

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The Effective Delivery of Poly(D,L-lactic Acid) (Juvelook) via Needle-Free Injection (CUREJET) for Facial Rejuvenation

  • 期刊论文

  • 发表日期：

    2025年12月13日

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  • Suk Bae Seo,
  • Jovian Wan,
  • Song Eun Yoon,
  • Isaac Kai Jie Wong,
  • Kar Wai Alvin Lee,
  • Deborah Chua,
  • Jin-Hyun Kim,
  • Won Lee,
  • Kyu-Ho Yi

摘要

Background

Poly(D,L-lactic acid) (PDLLA) is increasingly used for skin rejuvenation, utilizing innovative delivery systems like needle-free injectors to enhance patient comfort and efficacy.

Objective

To evaluate the clinical efficacy and safety of PDLLA delivered through a microjet injector and to assess the durability of its rejuvenating effect over 24 weeks.

Methods

This study involved 40 patients who underwent five treatment sessions of PDLLA (Juvelook) treatment via a needle-free microjet system. Efficacy was assessed through clinical evaluation (GAIS), patient satisfaction surveys, and 3D imaging analysis at baseline, 8 weeks, and 24 weeks.

Results

GAIS scores improved from 1.48 ± 0.32 at baseline to 1.90 ± 0.28 at 8 weeks and 2.16 ± 0.26 at 24 weeks (p < 0.001). Patient satisfaction increased from 3.38 ± 1.12 to 7.95 ± 0.86 (8 weeks) and 8.71 ± 0.69 (24 weeks). 3D imaging showed progressive vector displacement, with a mean displacement of 1.5 ± 0.4 mm at 8 weeks and 2.3 ± 0.5 mm at 24 weeks, indicating sustained lifting and textural improvement. These effects are attributed to the high-velocity microjet delivery mechanism, which enables uniform intradermal dispersion with minimal trauma.

Conclusion

PDLLA (Juvelook) delivered via needle-free injection (CUREJET, BAZ BIOMEDIC CO., LTD.) is a safe and effective modality for facial rejuvenation, offering a promising alternative to conventional methods. Further research is needed to explore long-term outcomes and mechanistic insights.

Level of Evidence IV

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.