Comparative 3D Analysis of Lip Rejuvenation: Investigating Effects Before and After Soft-Tissue Filler Compared with Controls

The aim of this study was to evaluate changes in lip metrics before and after facial rejuvenation treatment with hyaluronic acid-based fillers and to compare them with those of a control group using stereophotogrammetry (3D).

This study included 63 Caucasian women divided into Group C (<30 years, n=30) and Group H (>30 years, n=33), which was further divided into before (HT0) and after (HT1) lip augmentation with hyaluronic acid (HA). Eleven anthropometric landmarks were identified for linear, angular, and surface area measurements. Three photos were captured in Group C, while Group H had photos taken at T0 and T1. Statistical analysis was conducted using the Shapiro–Wilk test to evaluate normality, the Kruskal–Wallis test and one-way ANOVA. Tukey’s post hoc and pairwise comparison tests were performed to analyze differences between variables (P value < 0.05).

There were significant differences between lip width (ChR–ChL) and philtrum width (CphR–CphL) (P<.001). The total heights of the upper (Ls–Li) and lower vermilion lips (Sto–Li) increased, and the heights of the upper (Sn–Ls) and lower (Li–Sl) cutaneous lips decreased. The angles related to the philtrum (ChR–CphR–Ls, P<.001; ChL–CphL–Ls, P<.001) and nasolabial angle (Prn–Sn–Ls) (P<.001) exhibited significant differences. The surface areas of the upper, lower, and total vermilion lip showed significant differences (P<.001). Tukey’s test indicated no significant differences in surface area after lip augmentation between the HT1 and C groups.

Analysis of lip morphology after a filler procedure revealed a reversal of age-related changes, with increases in vermilion lip height and surface area comparable to those of younger individuals.

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