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Purpose <p>This study aims to evaluate changes in the coagulation profile of patients with knee periprosthetic infections (PJI) and determine its diagnostic value in this complication.</p> Methods <p>A prospective study was conducted with 112 patients who underwent revision surgery for total knee arthroplasty in a single tertiary hospital between January 2021 and December 2022.</p> Results <p>51 patients were diagnosed with PJI. D-dimer (<i>p</i> = 0.001), fibrinogen (<i>p</i> = 0.0007), platelets (0.01), and international normalized ratio (<i>p</i> = 0.01) were significantly higher in patients with PJI.</p> Conclusions <p>Patients with PJI display altered coagulation profile. The evaluation of coagulation-related markers has limited value for diagnosing PJI. Further studies are needed to understand the impact of such alterations on patients’ outcomes.</p>

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Alterations in coagulation profile of patients with periprosthetic joint infections

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月29日

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  • Augusto Carlos Maciel Saraiva,
  • Alan de Paula Mozella,
  • Hugo Alexandre de Araujo Barros Cobra,
  • Osamu de Sandes Kimura,
  • João Antonio Matheus Guimarães,
  • Helton Defino,
  • Ana Carolina Leal

摘要

Purpose

This study aims to evaluate changes in the coagulation profile of patients with knee periprosthetic infections (PJI) and determine its diagnostic value in this complication.

Methods

A prospective study was conducted with 112 patients who underwent revision surgery for total knee arthroplasty in a single tertiary hospital between January 2021 and December 2022.

Results

51 patients were diagnosed with PJI. D-dimer (p = 0.001), fibrinogen (p = 0.0007), platelets (0.01), and international normalized ratio (p = 0.01) were significantly higher in patients with PJI.

Conclusions

Patients with PJI display altered coagulation profile. The evaluation of coagulation-related markers has limited value for diagnosing PJI. Further studies are needed to understand the impact of such alterations on patients’ outcomes.