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Objective <p>To evaluate the real-world treatment practices and survival outcomes of patients with de novo metastatic nasopharyngeal carcinoma (dnMNPC) after the combination of programmed death-1(PD-1) inhibitors with chemotherapy.</p> Methods <p>We retrospectively gathered data from patients with dnMNPC who were treated with a combination of chemotherapy and PD-1 inhibitors between August 2019 and August 2023. Kaplan–Meier analysis and Cox proportional hazards regression model were used for statistical analyses.</p> Results <p>A total of 42 patients with dnMNPC were included. There were 22 and 20 patients who had oligometastasis (OM) (52.3%) and polymetastasis (PM) (47.6%), respectively. After systemic chemotherapy and PD-1 inhibitor treatment, 20 patients (47.6%) received locoregional radiotherapy. Over the entire course of chemotherapy and PD-1 inhibitor treatment, the patient cohort comprised 10 cases of complete response (23.8%), 27 cases of partial response (64.3%), 3 cases of stable disease (7.1%), and 2 cases of progressive disease (4.8%). The observed response rate was 88.1%. With a median follow-up duration of 19.4&#xa0;months, the 2-year progression-free survival (PFS) and overall survival (OS) were 32.0% and 70.7%, respectively. Patients with PM (PFS, <i>P</i> = 0.021; OS, <i>P</i> = 0.009) and had detectable EBV-DNA (PFS, <i>P</i> = 0.051; OS, <i>P</i> = 0.005) post-treatment had inferior PFS and OS.</p> Conclusions <p>The addition of PD-1 inhibitors to chemotherapy offers better clinical efficacy for patients with dnMNPC. Patients with OM and undetectable EBV-DNA after chemoimmunotherapy exhibit improved survival outcomes.</p>

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Real-world treatment practices and survival outcomes of patients with de novo metastatic nasopharyngeal carcinoma after chemoimmunotherapy

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月11日

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  • Qin Lin,
  • Yuan Zhou,
  • Lin-Feng Guo,
  • Guan-Zhong Lu,
  • San-Gang Wu

摘要

Objective

To evaluate the real-world treatment practices and survival outcomes of patients with de novo metastatic nasopharyngeal carcinoma (dnMNPC) after the combination of programmed death-1(PD-1) inhibitors with chemotherapy.

Methods

We retrospectively gathered data from patients with dnMNPC who were treated with a combination of chemotherapy and PD-1 inhibitors between August 2019 and August 2023. Kaplan–Meier analysis and Cox proportional hazards regression model were used for statistical analyses.

Results

A total of 42 patients with dnMNPC were included. There were 22 and 20 patients who had oligometastasis (OM) (52.3%) and polymetastasis (PM) (47.6%), respectively. After systemic chemotherapy and PD-1 inhibitor treatment, 20 patients (47.6%) received locoregional radiotherapy. Over the entire course of chemotherapy and PD-1 inhibitor treatment, the patient cohort comprised 10 cases of complete response (23.8%), 27 cases of partial response (64.3%), 3 cases of stable disease (7.1%), and 2 cases of progressive disease (4.8%). The observed response rate was 88.1%. With a median follow-up duration of 19.4 months, the 2-year progression-free survival (PFS) and overall survival (OS) were 32.0% and 70.7%, respectively. Patients with PM (PFS, P = 0.021; OS, P = 0.009) and had detectable EBV-DNA (PFS, P = 0.051; OS, P = 0.005) post-treatment had inferior PFS and OS.

Conclusions

The addition of PD-1 inhibitors to chemotherapy offers better clinical efficacy for patients with dnMNPC. Patients with OM and undetectable EBV-DNA after chemoimmunotherapy exhibit improved survival outcomes.