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Background <p>Fibrosis is a key pathological feature of autoimmune liver diseases (AILD). This study evaluates the diagnostic potential of apparent diffusion coefficient (ADC) values from diffusion-weighted imaging (DWI) for liver fibrosis staging, liver damage, and inflammation in AILD patients.</p> Methods <p>This retrospective study analyzed the diagnostic performance of ADC values from DWI in 157 AILD patients. Liver biopsy served as the gold standard for fibrosis staging. The relationship between ADC values and liver function markers (AST, ALT) and inflammatory cytokines (IL-17, TNF-α) was assessed. To evaluate diagnostic accuracy, ADC values were compared across different fibrosis stages (S0 to S4) and inflammation grades (G0 to G4).</p> Results <p>ADC values decreased progressively with increasing fibrosis stages and inflammation grades. Notably, ADC values were significantly lower in S4 compared to S0, with an AUC of 0.91. Pearson correlation analysis revealed significant negative correlations between ADC and serum IL-17 (<i>r</i> = -0.39, <i>p</i> &lt; 0.001), TNF-α (<i>r</i> = -0.43, <i>p</i> &lt; 0.001), as well as liver function markers, ALT (<i>r</i> = -0.49, <i>p</i> &lt; 0.001) and AST (<i>r</i> = -0.46, <i>p</i> &lt; 0.001). ROC analysis showed optimal ADC cut-off values for distinguishing fibrosis stages: 1.47 × 10<sup>−</sup>³ mm²/s for ≥ S1 (AUC = 0.90), 1.35 × 10<sup>−</sup>³ mm²/s for ≥ S2 (AUC = 0.88), 1.24 × 10<sup>−</sup>³ mm²/s for ≥ S3 (AUC = 0.90), and 1.12 × 10<sup>−</sup>³ mm²/s for S4 (AUC = 0.91).</p> Conclusion <p>This study highlights ADC values from DWI as a reliable non-invasive biomarker for assessing liver fibrosis and inflammation in AILD patients.</p>

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Diagnosis of liver fibrosis degree in autoimmune liver disease by magnetic resonance diffusion-weighted imaging

  • 期刊论文

  • 发表日期：

    2025年11月8日

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  • Yanyan Lu,
  • Jun Chen,
  • Ji Dong,
  • Xiao Jiang,
  • Bin Qiu

摘要

Background

Fibrosis is a key pathological feature of autoimmune liver diseases (AILD). This study evaluates the diagnostic potential of apparent diffusion coefficient (ADC) values from diffusion-weighted imaging (DWI) for liver fibrosis staging, liver damage, and inflammation in AILD patients.

Methods

This retrospective study analyzed the diagnostic performance of ADC values from DWI in 157 AILD patients. Liver biopsy served as the gold standard for fibrosis staging. The relationship between ADC values and liver function markers (AST, ALT) and inflammatory cytokines (IL-17, TNF-α) was assessed. To evaluate diagnostic accuracy, ADC values were compared across different fibrosis stages (S0 to S4) and inflammation grades (G0 to G4).

Results

ADC values decreased progressively with increasing fibrosis stages and inflammation grades. Notably, ADC values were significantly lower in S4 compared to S0, with an AUC of 0.91. Pearson correlation analysis revealed significant negative correlations between ADC and serum IL-17 (r = -0.39, p < 0.001), TNF-α (r = -0.43, p < 0.001), as well as liver function markers, ALT (r = -0.49, p < 0.001) and AST (r = -0.46, p < 0.001). ROC analysis showed optimal ADC cut-off values for distinguishing fibrosis stages: 1.47 × 10−³ mm²/s for ≥ S1 (AUC = 0.90), 1.35 × 10−³ mm²/s for ≥ S2 (AUC = 0.88), 1.24 × 10−³ mm²/s for ≥ S3 (AUC = 0.90), and 1.12 × 10−³ mm²/s for S4 (AUC = 0.91).

Conclusion

This study highlights ADC values from DWI as a reliable non-invasive biomarker for assessing liver fibrosis and inflammation in AILD patients.