Scholarlink

Purpose <p>This work aimed to evaluate the diagnostic performance of the CEUS LI-RADS and to further improve its ability to differentiate HCC from non-HCC malignancies by modifying the LR-M criteria.</p> Methods <p>This retrospective study included patients with a high risk of HCC who underwent CEUS examination. A subgroup of LR-M lesions was reassessed by applying different diagnostic criteria, including Criterion 1: early washout &lt; 60&#xa0;s; Criterion 2: Criterion 1 + marked washout within 4&#xa0;min; Criterion 3: early washout &lt; 45&#xa0;s; Criterion 4: washout onset—enhancement onset &lt; 30&#xa0;s. Diagnostic efficacy was assessed.</p> Results <p>A total of 1681 liver lesions were included. When LR-5 was used as a predictor of HCC, the sensitivities of Criterion 2 (84.3%), Criterion 3 (73.1%), and Criterion 4 (73.5%) were greater than that of Criterion 1 (67.3%; all <i>p</i> &lt; 0.01). The specificities of Criterion 1 (95.1%), Criterion 3 (94.2%), and Criterion 4 (94.6%) were similar and surpassed that of Criterion 2 (73.5%; all <i>p</i> &lt; 0.01). The PPVs of Criterion 1 (97.7%), Criterion 3 (97.5%), and Criterion 4 (97.7%) were similar and surpassed that of Criterion 2 (95.7%; all <i>p</i> &lt; 0.05).</p> Conclusion <p>The use of the washout onset time minus the enhancement onset time &lt; 30&#xa0;s as a new criterion for early washout could help improve the differential ability for HCC and non-HCC malignancies.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Incorporating new criteria can improve the ability of CEUS LI-RADS to differentiate HCC from non-HCC malignancies

  • 期刊论文

  • 发表日期：

    2025年9月30日

查看全文
  • Rong Wen,
  • Yuting Peng,
  • Ruizhi Gao,
  • Jinshu Pang,
  • Xiumei Bai,
  • Lanhui Qin,
  • Dongyue Wen,
  • Yuquan Wu,
  • Yiqiong Liang,
  • Yun He,
  • Liling Long,
  • Hong Yang

摘要

Purpose

This work aimed to evaluate the diagnostic performance of the CEUS LI-RADS and to further improve its ability to differentiate HCC from non-HCC malignancies by modifying the LR-M criteria.

Methods

This retrospective study included patients with a high risk of HCC who underwent CEUS examination. A subgroup of LR-M lesions was reassessed by applying different diagnostic criteria, including Criterion 1: early washout < 60 s; Criterion 2: Criterion 1 + marked washout within 4 min; Criterion 3: early washout < 45 s; Criterion 4: washout onset—enhancement onset < 30 s. Diagnostic efficacy was assessed.

Results

A total of 1681 liver lesions were included. When LR-5 was used as a predictor of HCC, the sensitivities of Criterion 2 (84.3%), Criterion 3 (73.1%), and Criterion 4 (73.5%) were greater than that of Criterion 1 (67.3%; all p < 0.01). The specificities of Criterion 1 (95.1%), Criterion 3 (94.2%), and Criterion 4 (94.6%) were similar and surpassed that of Criterion 2 (73.5%; all p < 0.01). The PPVs of Criterion 1 (97.7%), Criterion 3 (97.5%), and Criterion 4 (97.7%) were similar and surpassed that of Criterion 2 (95.7%; all p < 0.05).

Conclusion

The use of the washout onset time minus the enhancement onset time < 30 s as a new criterion for early washout could help improve the differential ability for HCC and non-HCC malignancies.