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Purpose <p>To assess the homogeneity of pancreatic iron deposition in non-transfusion dependent thalassemia (NTDT).</p> Methods <p>The segments (head, body, and tail) R2* of the pancreas were measured separately in 119 cases that underwent pancreatic magnetic resonance imaging multi-echo gradient sequences of NTDT and analyzed the consistency.</p> Results <p>The median R2* values for pancreas: head = 26.7 1/s, body = 26.5 1/s, tail = 24.9 1/s, and the analysis showed no significant differences in pancreatic segments R2* value (<i>P</i> = 0.204). There were no significant difference in pancreatic segments R2* values within the subgroup of sex, heart iron degree, liver iron degree and pancreatic iron degree (all <i>P</i> &gt; 0.05). There is a moderate correlation between the standard deviation and the&#xa0;coefficient of variation of R2* values for each segment of the pancreas and the mean value of the pancreas (<i>r</i> = 0.683, <i>P</i> &lt; 0.001; <i>r</i> = 0.411, <i>P</i> &lt; 0.001), R2* values were no different among pancreatic segments in the extremely severe iron overload group (with three times R2* the pancreatic Oiron overload threshold).</p> Conclusion <p>There were no significant differences in&#xa0;pancreatic iron deposition&#xa0;among the segments&#xa0;in NTDT, and R2* values for single-segment could be selected to assess the overall iron deposition of the pancreas.</p> Graphical abstract <p></p>

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Assessment of the distribution of pancreatic iron deposition in non-transfusion dependent thalassemia

  • 期刊论文

  • 发表日期：

    2025年6月23日

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  • Chaotian Luo,
  • Fei Peng,
  • Xiaojing Ning,
  • Cheng Tang,
  • Linlin Liang,
  • Mingrui Yang,
  • Yanyan Zhang,
  • Kaiming Guan,
  • Zengqin Liang,
  • Peng Peng

摘要

Purpose

To assess the homogeneity of pancreatic iron deposition in non-transfusion dependent thalassemia (NTDT).

Methods

The segments (head, body, and tail) R2* of the pancreas were measured separately in 119 cases that underwent pancreatic magnetic resonance imaging multi-echo gradient sequences of NTDT and analyzed the consistency.

Results

The median R2* values for pancreas: head = 26.7 1/s, body = 26.5 1/s, tail = 24.9 1/s, and the analysis showed no significant differences in pancreatic segments R2* value (P = 0.204). There were no significant difference in pancreatic segments R2* values within the subgroup of sex, heart iron degree, liver iron degree and pancreatic iron degree (all P > 0.05). There is a moderate correlation between the standard deviation and the coefficient of variation of R2* values for each segment of the pancreas and the mean value of the pancreas (r = 0.683, P < 0.001; r = 0.411, P < 0.001), R2* values were no different among pancreatic segments in the extremely severe iron overload group (with three times R2* the pancreatic Oiron overload threshold).

Conclusion

There were no significant differences in pancreatic iron deposition among the segments in NTDT, and R2* values for single-segment could be selected to assess the overall iron deposition of the pancreas.

Graphical abstract